N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide)

Base Information

• Chemical Name: N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide)
• CAS No.: 1415906-22-7
• Molecular Formula: C₁₈H₁₄N₄O₄S
• Molecular Weight: 382.4
• Mol file: 1415906-22-7.mol

Synonyms:N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide)

Chemical Property of N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide)

There total 1 articles about N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 2-cyanoacetate (105-56-6) + dapsone (80-08-0) → N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide) (1415906-22-7)

Guidance literature:

at 220 ℃; for 2h;

DOI:10.1248/cpb.c12-00292

Reference yield: 91.0%

N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide) (1415906-22-7) + 4-Chlorophenyl isothiocyanate (2131-55-7) → N,N'-(4,4'-sulfonylbis(4,1-phenylene))bis(4-amino-3-(4-chlorophenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxamide)

Guidance literature:

With sulfur; triethylamine; In ethanol; N,N-dimethyl-formamide; at 60 ℃; for 6h;

DOI:10.1055/s-0032-1323660 DOI:10.1055/s-0032-1323660

Reference yield: 89.0%

N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyanoacetamide) (1415906-22-7) + acetylacetone (123-54-6,81235-32-7) → 1,1'-[4,4'-sulfonylbis(4,1-phenylene)]bis(4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile) (1415906-23-8)

Guidance literature:

With piperidine; In ethanol; for 5h; Reflux;

DOI:10.1248/cpb.c12-00292

upstream raw materials:

ethyl 2-cyanoacetate

dapsone

Downstream raw materials:

N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyano-2-(5-hydroxy-1,3-dithian-2-ylidene)acetamide)

N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyano-2-(1,3-dithiolan-2-ylidene)acetamide)

N,N'-[4,4'-sulfonylbis(4,1-phenylene)]bis(2-cyano-3,3-bis(methylthio)acrylamide)

2,2'-[4,4'-sulfonylbis(4,1-phenylene)]bis(8-amino-3-methyl-1-oxo-6-p-tolyl-1,2-dihydroisoquinoline-7-carbonitrile)