80-08-0 Usage
Description
4,4'-Diaminodiphenylsulfone is an organic compound with the chemical formula C12H12N2O2S. It is a white crystalline solid that is soluble in water and has a melting point of 187-191°C. It is a derivative of diphenylsulfone, with two amine groups attached to the para positions of the phenyl rings.
Uses
Used in Pharmaceutical Industry:
4,4'-Diaminodiphenylsulfone is used as an antibacterial agent for the treatment of dermatitis herpetiformis. It is effective in suppressing the symptoms of this skin condition, which is characterized by a severe rash and intense itching.
Used in Chemical Industry:
4,4'-Diaminodiphenylsulfone is used as a hardening agent in the curing of epoxy resins. It enhances the mechanical properties and chemical resistance of the cured resin, making it suitable for various applications, such as coatings, adhesives, and composite materials.
Used in Antimicrobial Applications:
4,4'-Diaminodiphenylsulfone is used as an antibacterial and leprostatic agent. It exhibits broad-spectrum antimicrobial activity against various bacteria and fungi, making it a valuable compound for the development of new antimicrobial agents and treatments.
Originator
Avlosulfon,Ayerst,US,1957
Indications
Although dapsone (Avlosulfon) is most often used as an
antimicrobial agent, it has important antiinflammatory
properties in many noninfectious skin diseases. The mechanism of action of dapsone in skin disease is
not clear.Most of the cutaneous diseases for which it is
effective manifest inflammation and are characterized
by an infiltration of neutrophils; the drug’s antiinflammatory
effect may arise from its inhibition of intracellular
neutrophil reactions mediated by myeloperoxidase
and hydrogen peroxide or from its scavenging of reactive
oxygen species, which inhibits inflammation.
Indications
Although dapsone (Avlosulfon) was once used in the
treatment and prophylaxis of chloroquine-resistant P.
falciparum malaria, the toxicities associated with its
administration (e.g., agranulocytosis, methemoglobinemia,
hemolytic anemia) have severely reduced its use.
Occasionally dapsone has been added to the usual
chloroquine therapeutic regimen for the prophylaxis of
chloroquine-resistant P. falciparum malaria. It is also
used in combination therapy for leprosy.
Manufacturing Process
p-Chloronitrobenzene is reacted with NaSO2C6H5NHCOCH3 to give as an
intermediate, O2NC6H5SO2C6H5NHCOCH3 which is then reduced and
deacetylated to give the product, dapsone. Alternatively, benzene and sulfuric
acid react to give phenyl sulfone which is nitrated, then reduced to give
dapsone.
Synthesis Reference(s)
Synthesis, p. 640, 1981 DOI: 10.1055/s-1981-29557
Antimicrobial activity
Dapsone is active against many bacteria and some protozoa.
Fully susceptible strains of M. leprae are inhibited by a little
as 0.003 mg/L. It is predominantly bacteristatic. Resistance
is associated with mutations in the folP1 gene involved in the
synthesis of para-aminobenzoic acid.
Acquired resistance
Resistance to high levels is acquired by several sequential mutations.
As a result of prolonged use of dapsone monotherapy,
acquired resistance emerged in patients with multibacillary leprosy
in many countries. Initial resistance also occurs in patients
with both paucibacillary and multibacillary leprosy. Thus,
leprosy should always be treated with multidrug regimens.
Resistance of M. leprae to dapsone (and other anti-leprosy
drugs) may now be determined by use of DNA microarrays.
Air & Water Reactions
Sensitive to oxidation and light. Insoluble in water.
Reactivity Profile
4,4'-Diaminodiphenylsulfone can neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Incompatible with strong oxidizing agents. Also incompatible with epoxy resins under uncontrolled conditions .
Fire Hazard
4,4'-Diaminodiphenylsulfone is probably combustible.
Pharmaceutical Applications
The most effective of a number of sulfonamide derivatives to
be tested against leprosy. The dry powder is very stable. It is
only slightly soluble in water.
Pharmacokinetics
Oral absorption: >90%
Cmax 100 mg oral: c. 2 mg/L after 3–6 h
Plasma half-life: 10–50 h
Plasma protein binding: c. 50%
It is slowly but almost completely absorbed from the intestine
and widely distributed in the tissues, but selectively
retained in skin, muscle, kidneys and liver. It is metabolized
by N-oxidation and also by acetylation, which is subject to the
same genetic polymorphism as isoniazid. The elimination
half-life is consequently very variable, but on standard
therapy the trough levels are always well in excess of inhibitory
concentrations. It is mostly excreted in the urine: in the
unchanged form (20%), as N-oxidation products (30%) and
as a range of other metabolites.
Clinical Use
Dapsone (4,4 -sulfonylbisbenzeneamine; 4,4 -sulfonyldianiline;p,p -diaminodiphenylsulfone; or DDS [Avlosulfon])occurs as an odorless, white crystalline powder that is veryslightly soluble in water and sparingly soluble in alcohol.The pure compound is light stable, but traces of impurities,including water, make it photosensitive and thus susceptibleto discoloration in light. Although no chemical change is detectablefollowing discoloration, the drug should be protectedfrom light.Dapsone is used in the treatment of both lepromatous andtuberculoid types of leprosy. Dapsone is used widely for allforms of leprosy, often in combination with clofazimine andrifampin. Initial treatment often includes rifampin with dapsone,followed by dapsone alone. It is also used to preventthe occurrence of multibacillary leprosy when given prophylactically.Dapsone is also the drug of choice for dermatitis herpetiformisand is sometimes used with pyrimethamine for treatmentof malaria and with trimethoprim for PCP.Serious side effects can include hemolytic anemia,methemoglobinemia, and toxic hepatic effects. Hemolyticeffects can be pronounced in patients with glucose-6-phosphatedehydrogenase deficiency. During therapy, all patientsrequire frequent blood counts.
Clinical Use
Dapsone is approved for the treatment of an autoimmune
blistering skin disease, dermatitis herpetiformis.
This intensely pruritic eruption is characterized
histologically by a dense dermal infiltration of neutrophils
and subepidermal blisters. Other skin diseases
in which dapsone is helpful are linear immunoglobulin
A (IgA) dermatosis, subcorneal pustular dermatosis,
leukocytoclastic vasculitis, and a variety of rarer eruptions
in which neutrophils predominate, including some
forms of cutaneous lupus erythematosus.
Clinical Use
Leprosy (multidrug regimens)
Prophylaxis of malaria, treatment of chloroquine-resistant malaria (in
combination with pyrimethamine)
Prophylaxis of toxoplasmosis (in combination with pyrimethamine)
Prophylaxis (monotherapy) and treatment (in combination with
trimethoprim) of Pneumocystis jirovecii pneumonia
Dermatitis herpetiformis and related skin disorders
Side effects
Although usually well tolerated at standard doses, gastrointestinal
upsets, anorexia, headaches, dizziness and insomnia may
occur. Less frequent reactions include skin rashes, exfoliative
dermatitis, photosensitivity, peripheral neuropathy (usually
in non-leprosy patients), tinnitus, blurred vision, psychoses,
hepatitis, nephrotic syndrome, systemic lupus erythematosus
and generalized lymphadenopathy.
The term ‘dapsone syndrome’ is applied to a skin rash and
fever occurring 2–8 weeks after starting therapy and sometimes
accompanied by lymphadenopathy, hepatomegaly,
jaundice and/or mononucleosis.
Blood disorders include anemia, methemoglobinemia,
sulfhemoglobinemia, hemolysis (notably in patients with
glucose-
6-phosphate dehydrogenase deficiency), mononucleosis,
leukopenia and, rarely, agranulocytosis. Severe anemia
should be treated before patients receive dapsone.
The incidence of adverse reactions declined in the 1960s
but reappeared around 1982 when multidrug therapy was
introduced, and may represent an unexplained interaction
with rifampicin.
Safety Profile
Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: agranulocytosis, change in tubules and other kidney changes, cyanosis, effect on joints, hemolysis with or without anemia, jaundice, methemoglobinemiacarboxyhemoglobinemia, retinal changes, somnolence. Experimental reproductive effects. Can cause hepatitis, dermatitis, and neuritis. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. Used in leprosy treatment and veterinary medicine. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFONATES.
Synthesis
Dapsone, 4,4-diaminodiphenylsulfone (34.2.3), is synthesized from either 4-chloronitrobenzene or from the sodium salt of 4-acetamidobenzenesulfonic acid. Reacting 4-chloronitrobenzene with sodium sulfide gives 4,4-dinitrodiphenylthioester (34.2.1), and oxidation of the sulfur atom in this compound using potassium dichromate in sulfuric acid gives 4,4-dinitrodiphenylsulfone (34.2.2). Reduction of the nitro group in the resulting compound using tin dichloride in hydrochloric acid makes the desired dapsone.
It has also been suggested to reduce the nitro group to an amino group, protect it with an acetyl protection, oxidize the sulfur atom to a sulfone using potassium dichromate, and then remove the protective acetyl group by hydrolysis.
Another way of the synthesis of dapsone begins with 4-acetamidobenzenesulfonic acid, which is reacted with 4-chloronitrobenzene at high temperatures to give 4-acetamido-4- nitrodiphenylsulfone (34.2.4). Reducing the nitro group in this compound with tin dichloride in hydrochloric acid along with the simultaneous hydrolysis of the acetyl group under the reaction conditions gives the desired dapsone.
Drug interactions
Potentially hazardous interactions with other drugsAntivirals: increased risk of ventricular arrhythmias
with saquinavir - avoid.
Metabolism
Dapsone undergoes enterohepatic recycling. Dapsone is
acetylated to monoacetyldapsone, the major metabolite,
and other mono and diacetyl derivatives. Acetylation
shows genetic polymorphism. Hydroxylation is the other
major metabolic pathway resulting in hydroxylamine
dapsone, which may be responsible for dapsoneassociated methaemoglobinaemia and haemolysis.
Dapsone is mainly excreted in the urine, only 20% of a
dose as unchanged drug.
Check Digit Verification of cas no
The CAS Registry Mumber 80-08-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 80-08:
(4*8)+(3*0)+(2*0)+(1*8)=40
40 % 10 = 0
So 80-08-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H10O2S.C7H6N2O5/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12;1-4-2-5(8(11)12)3-6(7(4)10)9(13)14/h1-10H;2-3,10H,1H3
80-08-0Relevant articles and documents
Novel catalyst based on mono- and di-vanadium substituted Keggin polyoxometalate incorporated in poly(acrylic acid-co-acrylamide) polymer for the oxidation of sulfides
Frenzel, Romina A.,Romanelli, Gustavo P.,Pizzio, Luis R.
, p. 8 - 16 (2018)
Composite materials based on [PVxW12-xO40](3+x)? with x = 1 or 2 (PVW and PV2W respectively), included in poly(acrylic acid-co-acrylamide) gel (PAACA), were synthesized. The samples were characterized by different techniques such as FT-IR, 31P MAS-NMR, 51V-NMR, XRD, DTA-TGA, UV–vis DRS, and the acidic properties were estimated by means of potentiometric titration with n-butylamine. Samples containing 10, 20 and 30% (w/w) of polyoxotungstovanadate (POTV) were prepared by inclusion of the POTV in the polymer during its synthesis. According to Fourier transform infra-red and magic angle spinning-nuclear magnetic resonance studies, the predominat anion present in the samples is [PVxW12-xO40](3+x)?, and there is no evidence of its decomposition during the synthesis of hybrid materials and the drying step. According to XRD results, these anions are greatly dispersed in the PAACA or present as amorphous phases. UV–vis DRS data reveal that the samples synthesized using POTV with two vanadium atoms (PAACA-PV2W) exhibit lower values of absorption edge energy than those prepared using PVW (PAACA-PVW), which correlates with a higher oxidizing capacity. The potentiometric titration shows strong acid sites of the hybrid materials, and their number increases with the number of vanadium atoms and with the amount of POTV incorporated in the PAACA grid. The hybrid materials prepared by inclusion of POTV during the polymer synthesis exhibit appropriate physicochemical features to catalyze the oxidation of diphenyl sulfide (DPS) to its sulfone employing acetonitrile as solvent H2O2 as a green oxidant. The samples with 30% w/w of POVT, which show higher catalytic performance, are suitable for the DPS oxidation and can be reused without remarkable drop of their catalytic activity. Furthermore, they show high activity as a catalyst in the oxidation reaction of 4,4′-diamino diphenyl sulfide to the corresponding sulfone (dapsone) used for malaria treatment.
Regioselective C-H Thioarylation of Electron-Rich Arenes by Iron(III) Triflimide Catalysis
Dodds, Amy C.,Sutherland, Andrew
, p. 5922 - 5932 (2021/05/04)
A mild and regioselective method for the preparation of unsymmetrical biaryl sulfides using iron(III) catalysis is described. Activation of N-(arylthio)succinimides using the powerful Lewis acid iron(III) triflimide allowed the efficient thiolation of a range of arenes, including anisoles, phenols, acetanilides, and N-heterocycles. The method was applicable for the late-stage thiolation of tyrosine and tryptophan derivatives and was used as the key step for the synthesis of pharmaceutically relevant biaryl sulfur-containing compounds such as the antibiotic dapsone and the antidepressant vortioxetine. Kinetic studies revealed that while N-(arylthio)succinimides bearing electron-deficient arenes underwent thioarylation catalyzed entirely by iron(III) triflimide, N-(arylthio)succinimides with electron-rich arenes displayed an autocatalytic mechanism promoted by the Lewis basic product.
Palladium-catalyzed one-step synthesis of symmetrical diaryl sulfones from aryl halides and a sulfur dioxide surrogate
Tanaka, Hiromichi,Konishi, Hideyuki,Manabe, Kei
supporting information, p. 760 - 763 (2019/08/02)
A convenient method for the one-step synthesis of symmetrical diaryl sulfones from aryl halides has been developed. A keystone of the method is the use of K2S2O5, which can be easily and safely handled, as a sulfur dioxide surrogate. The palladium catalyst bearing P(t-Bu)3 as a ligand enables formation of the desired sulfones without significant formation of byproducts.
