(2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone

Base Information

• Chemical Name: (2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone
• CAS No.: 939970-49-7
• Molecular Formula: C₁₉H₂₃NO₅S
• Molecular Weight: 377.461
• Mol file: 939970-49-7.mol

Synonyms:(2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone

Chemical Property of (2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone

There total 1 articles about (2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-methoxycyclohexanone (13482-23-0) + 3-(3',4',5'-trimethoxyphenyl)-3-oxopropanenitrile (50606-35-4) → (2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone (939970-49-7)

Guidance literature:

With morpholine; sulfur; for 21h;

DOI:10.1021/jm070050f

Reference yield: 57.0%

(2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone (939970-49-7) + acetic anhydride (108-24-7) → N-[6-methyloxy-3-(3,4,5-trimethoxybenzoyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]acetamide (939970-53-3)

Guidance literature:

With pyridine; for 2h; Heating;

DOI:10.1021/jm070050f

Reference yield:

(2-amino-6-methoxy-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(3,4,5-trimethoxyphenyl)methanone (939970-49-7) → C19H19NO5S

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / pyridine / 2 h / Heating

2: 51 percent / H₂O / Pd/C / 20 h / 130 °C

3: 57 percent / aq. NaOH / ethanol / 5 h / Heating

With pyridine; sodium hydroxide; water; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm070050f

upstream raw materials:

4-methoxycyclohexanone

3-(3',4',5'-trimethoxyphenyl)-3-oxopropanenitrile

Downstream raw materials:

N-[6-methyloxy-3-(3,4,5-trimethoxybenzoyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl]acetamide

N-[6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophen-2-yl]acetamide