13482-23-0Relevant academic research and scientific papers
Ammonium Tungstate as an Effective Catalyst for Selective Oxidation of Alcohols to Aldehydes or Ketones with Hydrogen Peroxide under Water - A Synergy of Graphene Oxide
Fu, Huihui,Hu, Chuanfeng,Huang, Zhida,Zhou, Jianhao,Peng, Xinhua
, p. 447 - 451 (2018)
Ammonium tungstate was found to be a facile and efficient catalyst for selective oxidation of alcohols to the corresponding carbonyl compounds with hydrogen peroxide as oxidant. Heterogeneous graphene oxide as acid effectively intensified the transformations and resulted in excellent yields. The use of water as solvent rendered the reactions promising both economically and environmentally.
Synthesis method of 4-substituent cyclohexanone
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Paragraph 0034; 0036-0037; 0042-0045, (2021/05/12)
The invention discloses a synthesis method of 4-substituent cyclohexanone, which comprises the following steps: by taking a 4-substituent phenol compound as a raw material, carrying out catalytic hydrogenation on 4-substituent phenol to obtain 4-substituent cyclohexanol, and then oxidizing the 4-substituent cyclohexanol by taking oxygen-containing gas as an oxidant to prepare the 4-substituent cyclohexanone. The oxygen-containing gas is used as the oxidizing agent, the oxygen-containing gas is low in price, good in reaction selectivity, high in oxidation reaction yield and environment-friendly, and is an ideal clean oxidizing agent; in addition, the whole synthesis process is simple, mild in condition, simple in post-treatment, green, environment-friendly and suitable for large-scale industrial production.
Synthesis method of 4-substituent cyclohexanone liquid crystal intermediate
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Paragraph 0048; 0050-0051, (2021/05/19)
The invention discloses a synthesis method of a 4-substituent cyclohexanone liquid crystal intermediate, which comprises the following step: carrying out oxidation catalytic reaction on 4-substituent cyclohexanol under the action of trichloroisocyanide urea to obtain the 4-substituent cyclohexanone liquid crystal intermediate. The method is high in reaction selectivity, high in yield, environment-friendly, simple in post-treatment and suitable for industrial production.
POLITAG-Pd(0) catalyzed continuous flow hydrogenation of lignin-derived phenolic compounds using sodium formate as a safe H-source
Campana, Filippo,Ferlin, Francesco,Silvetti, Matteo,Trombettoni, Valeria,Vaccaro, Luigi,Valentini, Federica
, (2021/07/09)
Phenols are aromatic biobased compounds and as they are accessible from lignin depolymerization, they can be a useful platform chemicals to produce value-added products. Herein we report our recent investigations on the definition of an approach to the efficient continuous flow selective hydrogenation of phenols in water. Our protocol is based on the use of sodium formate as a clean and safe hydrogen source in combination with our newly defined heterogeneous POLITAG-Pd(0) catalytic system. POLITAG is a polymeric heterogeneous support decorated with pincer-type ionic ligands proven to be highly efficient for the stabilization of Pd(0) nanoparticles. The results obtained are remarkable in comparison with other protocols that employ sodium formate as H-source. Indeed, our investigation has been extended to a variety of differently substituted phenolic compounds that have been hydrogenated with excellent to good selectivity in continuous flow conditions. Durability of the catalyst has been also tested with a representative continuous processing of over 100 mmol that showed no loss in efficiency and minimal metal leaching.
Highly Selective Hydrogenation of Phenols to Cyclohexanone Derivatives Using a Palladium@N-Doped Carbon/SiO2Catalyst
Sheng, Xueru,Wang, Chao,Wang, Wentao
supporting information, p. 2425 - 2431 (2021/11/16)
A new palladium-based heterogeneous material was synthesized by means of immobilization of Pd(OAc)2/1,10-phenanthroline on commercially available SiO2and subsequent pyrolysis at 600 °C for 2 h in air, namely, a Pd@N-doped carbon/SiO2catalyst. The obtained catalyst was studied by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), and X-ray photoelectron spectroscopy (XPS) techniques, and was effectively applied in the highly selective hydrogenation of phenols to give the corresponding cyclohexanone derivatives with 93-98% yields at 100 °C under 0.4 MPa H2in EtOH. It was demonstrated that introducing nitrogen could effectively promote the Pd dispersion and enhance the electronic interaction of Pd, both of which facilitate the improvement of the catalytic activity and selectivity. The likely reaction pathway was outlined to elucidate the selective hydrogenation mechanism according to experimental results.
Synthetic method of cis-4-methoxycyclohexyl-1-carbamic acid
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Paragraph 0019-0023, (2019/06/27)
The invention provides a synthetic method of cis-4-methoxycyclohexyl-1-carbamic acid. The synthetic method includes the steps of catalytic hydrogenation, oxidative reaction, replacement reaction and hydrolytic reaction; the hydrolytic reaction is carried out in a microreactor, with a Jones reagent acting as an oxidant; barium hydroxide octahydrate is used as an alkaline material in the hydrolyticreaction. The synthetic method has few steps and shorter reaction time; the salt content in reaction wastewater is low, the content of heavy metals is low, and discharged waste is little; the finishedproduct has the content of 98% and above; the total reaction yield is 45% and above.
A New Route to Cyclohexanone using H2CO3 as a Molecular Catalytic Ligand to Boost the Thorough Hydrogenation of Nitroarenes over Pd Nanocatalysts
Zhao, Tian-Jian,Zhang, Jun-Jun,Zhang, Bing,Liu, Yong-Xing,Lin, Yun-Xiao,Wang, Hong-Hui,Su, Hui,Li, Xin-Hao,Chen, Jie-Sheng
, p. 2837 - 2842 (2019/05/27)
Carbon dioxide has been important in green chemistry, especially in catalytic and chemical engineering applications. While exploring CO2 to produce cyclohexanone for nylon or nylon 66 that is currently produced with low yields using harsh catalytic methods, we made the exciting discovery that carbonic acid, generated from dissolved CO2 in water, was utilized as molecular catalytic ligand to produce cyclohexanone via the hydrogenation of nitrobenzene in aqueous solution that uses Pd catalysts with a total yield higher than 90 %. Importantly, the gaseous nature of catalytic ligand H2CO3 profoundly simplifies post-catalysis cleanup unlike liquid or solid catalysts. This new green catalysis strategy demonstrated the universality for hydrogenation of aromatic compounds like aniline and N-methylaniline and could be broadly applicable in other catalytic field like artificial photosynthesis and electrocatalytic organic synthesis.
PYRIMIDINE-BASED ANTIPROLIFERATIVE AGENTS
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Page/Page column 172; 209; 211, (2018/02/28)
This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
Preparation method of p-methoxycyclohexanone
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Paragraph 0023; 0025; 0028; 0030; 0032; 0035, (2018/09/11)
The invention discloses a preparation method of p-methoxycyclohexanone. The preparation method comprises the steps that p-methoxyphenol is subjected to a hydrogenation reduction reaction under existence of a catalyst and a solvent to prepare p-methoxycyclohexanol; and p-methoxycyclohexanol is subjected to an oxidation reaction under existence of an oxidizing agent and a solvent to prepare p-methoxycyclohexanone. The target product can be obtained only by conducting reduction and oxidation reactions on p-methoxyphenol, p-methoxycyclohexanol obtained through the reduction reaction does not needto be purified and is directly used in the oxidation reaction, the technology is simple and easy to operate, the raw materials are wide in source, the production cost is low, and the preparation method is suitable for industrialized production.
Novel spirodecenol compound and preparation method thereof
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Paragraph 0034; 0035, (2018/05/16)
The invention discloses a novel spirodecenol compound and a preparation method thereof, and belongs to the technical field of pesticide synthesis. The invention adopts the key point that the novel spirodecenol compound has a structure as described in the specification. The invention also discloses a novel spirodecenol compound and a preparation method thereof. According to the invention, a novel spirodecenol compound is synthesized by a new method, a reaction process is simple and easy to operate, raw materials are cheap and easy to obtain, the reaction efficiency is high, the repeatability isgood, the insecticidal activity effect is obvious, and the spirodecenol compound has a good application prospect.
