(6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid

Base Information

• Chemical Name: (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid
• CAS No.: 1429753-23-0
• Molecular Formula: C₂₆H₃₉N₅O₉SSe
• Molecular Weight: 676.65
• Mol file: 1429753-23-0.mol

Synonyms:(6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid

Chemical Property of (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid

There total 8 articles about (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

GLUTATHIONE (70-18-8) + C32H46N4O6Se2 → (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid (1429753-23-0)

Guidance literature:

With rose bengal; In water; acetonitrile; for 1h; Irradiation;

DOI:10.1002/adsc.202100751

Reference yield: 57.0%

GLUTATHIONE (70-18-8) + (S)-2-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)ethaneseleninic acid (1429753-17-2) → (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid (1429753-23-0)

Guidance literature:

In water; acetonitrile; for 2h;

DOI:10.3390/molecules18021963

Reference yield:

(7R,12R,17S)-17-amino-7-((tert-butoxycarbonyl)amino)-12-((carboxymethyl)carbamoyl)-3,6,14-trioxo-1-phenyl-2-oxa-10-thia-9-selena-5,13-diazaoctadecan-18-oic acid → (6S,14R,19S)-19-amino-6-benzyl-14-((carboxymethyl)carbamoyl)-2,2-dimethyl-4,7,16-trioxo-3-oxa-12-thia-11-selena-5,8,15-triazaicosan-20-oic acid (1429753-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dithio-D,L-threitol / acetonitrile; water / 0.5 h

2: rose bengal / acetonitrile; water / 1 h / Irradiation

With 1,4-dithio-D,L-threitol; rose bengal; In water; acetonitrile;

DOI:10.1002/adsc.202100751

upstream raw materials:

(S)-tert-butyl (1-oxo-3-phenyl-1-((2-selenocyanatoethyl)amino)propan-2-yl)carbamate

GLUTATHIONE

(S)-2-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)ethaneseleninic acid

(S)-Se-(2-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)ethyl) 2-phenylethaneselenoate