methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Base Information

Chemical Name:methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate
CAS No.:1350658-99-9
Molecular Formula:CH₄O₃S*C₁₉H₁₆F₂N₈O₂
Molecular Weight:522.492
Hs Code.:

Synonyms:methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Suppliers and Price of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

There total 11 articles about methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1350653-20-1
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-5-yl}carbamate

: 1350658-99-9
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Guidance literature:: In 1,4-dioxane; ethanol; water; at 20 ℃;

Reference yield:

: 113237-20-0
2,6-dichloro-5-fluoropyridine-3-carboxamide

: 1350658-99-9
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: zinc; acetic acid / methanol / 24 h / Reflux

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

3.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux

4.1: boron trifluoride diethyl etherate; isopentyl nitrite / tetrahydrofuran / -10 - 0 °C

4.2: 0.5 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: bis(tri-n-butyltin) / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

7.1: hydrogen; pyridine / palladium 10% on activated carbon / 20 °C

8.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

9.1: 1,4-dioxane; ethanol; water / 20 °C

With pyridine; boron trifluoride diethyl etherate; hydrogen; bis(tri-n-butyltin); caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic anhydride; zinc; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 1034667-22-5
5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine

: 1350658-99-9
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate mesylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate; isopentyl nitrite / tetrahydrofuran / -10 - 0 °C

1.2: 0.5 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: bis(tri-n-butyltin) / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

4.1: hydrogen; pyridine / palladium 10% on activated carbon / 20 °C

5.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: 1,4-dioxane; ethanol; water / 20 °C

With pyridine; boron trifluoride diethyl etherate; hydrogen; bis(tri-n-butyltin); caesium carbonate; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;