2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

Base Information

Chemical Name:2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester
CAS No.:1620874-85-2
Molecular Formula:C₁₇H₁₅ClN₂O₆
Molecular Weight:378.769
Hs Code.:

Synonyms:2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

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Chemical Property of 2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

Chemical Property:

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Technology Process of 2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

There total 7 articles about 2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620874-84-1
5-hydroxy-4-(4-methylbenzoylamino)-2-nitrobenzoic acid ethyl ester

: 1620874-85-2
2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

Guidance literature:: With sulfuryl dichloride; diisopropylamine; In 1,4-dioxane; at 50 ℃; for 1h; Inert atmosphere;

Reference yield:

: 212118-11-1
3-methoxy-4-(2,2,2-trifluoroacetamido)benzoic acid

: 1620874-85-2
2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; sulfuric acid / 10 - 20 °C

2.1: sodium hydroxide / water / 100 °C / Inert atmosphere

2.2: 20 °C / Cooling with ice

3.1: hydrogenchloride / 36 h / 80 °C

4.1: 1,4-dioxane / 1.5 h / 95 °C

5.1: diisopropylamine; sulfuryl dichloride / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

With hydrogenchloride; sulfuryl dichloride; sulfuric acid; nitric acid; diisopropylamine; sodium hydroxide; In 1,4-dioxane; water;

Reference yield:

: 600713-80-2
5-methoxy-2-nitro-4-(2,2,2-trifluoroacetamido)benzoic acid

: 1620874-85-2
2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 100 °C / Inert atmosphere

1.2: 20 °C / Cooling with ice

2.1: hydrogenchloride / 36 h / 80 °C

3.1: 1,4-dioxane / 1.5 h / 95 °C

4.1: diisopropylamine; sulfuryl dichloride / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

With hydrogenchloride; sulfuryl dichloride; diisopropylamine; sodium hydroxide; In 1,4-dioxane; water;