(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Base Information

Chemical Name:(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid
CAS No.:401606-66-4
Molecular Formula:C₄₃H₆₃N₃O₁₀Si
Molecular Weight:810.073
Hs Code.:

(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Synonyms:(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

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Chemical Property of (2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

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Technology Process of (2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

There total 5 articles about (2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 401606-65-3
C₅₂H₈₁N₃O₁₂Si₂

: 401606-66-4
(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Guidance literature:: With lithium hydroxide; In tert-butyl alcohol; at 20 ℃; for 16h;
DOI:10.1021/ja017277z

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 401606-66-4
(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 454 mg / DEBPT; i-Pr₂NEt₂ / tetrahydrofuran / 18 h / 20 °C

2: 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

3: 143 mg / aq. LiOH / 2-methyl-propan-2-ol / 16 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide; i-Pr₂NEt₂; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja017277z

Reference yield:

: (2S,3R)-3-[3-((1R,2R)-2-Amino-1-ethyl-3-methoxymethoxy-1-methyl-propoxy)-4-benzyloxy-phenyl]-2-benzyloxycarbonylamino-3-hydroxy-propionic acid ethyl ester

: 401606-66-4
(2S,3R)-3-{3-[(1R,2R)-2-((S)-2-Amino-3-methyl-butyrylamino)-1-ethyl-3-methoxymethoxy-1-methyl-propoxy]-4-benzyloxy-phenyl}-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 454 mg / DEBPT; i-Pr₂NEt₂ / tetrahydrofuran / 18 h / 20 °C

2: 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

3: 143 mg / aq. LiOH / 2-methyl-propan-2-ol / 16 h / 20 °C

With 2,6-dimethylpyridine; lithium hydroxide; i-Pr₂NEt₂; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja017277z