4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester
CAS No.:566942-89-0
Molecular Formula:C₄₅H₆₇NO₂₄
Molecular Weight:1006.02
Hs Code.:

4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-<i>tert</i>-butyl ester

Synonyms:4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

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Chemical Property of 4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

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Technology Process of 4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

There total 11 articles about 4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-benzyloxycarbonyl-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: 566942-89-0
4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;
DOI:10.1039/b210503a

Reference yield:

: 221344-09-8
(1S,2S,4R,5S)-4,5-Dihydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

: 566942-89-0
4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₂SnO / benzene / 8 h / Heating

1.2: 53 percent / CsF / 1,2-dimethoxy-ethane / 4 h

2.1: 20 percent / TfOH / CH₂Cl₂ / 20 h / Heating

3.1: H₂ / Pd/C / methanol / 3 h / 20 °C

With trifluorormethanesulfonic acid; hydrogen; di(n-butyl)tin oxide; palladium on activated charcoal; In methanol; dichloromethane; benzene;
DOI:10.1039/b210503a

Reference yield:

: N-{(2S,3R,4R,5S,6R)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl}-acetamide

: 566942-89-0
4-[5-acetoxy-6-acetoxymethyl-3-acetylamino-4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-5-(1-carboxy-ethoxy)-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / PPTS / acetonitrile / 50 °C

2: TFA / CH₂Cl₂ / 4 h / 0 °C

3: pyridine / 2 h / 0 °C

4: TDAF / tetrahydrofuran / 20 h / -5 °C

5: DBU / CH₂Cl₂ / 5 h / 20 °C

6: 20 percent / TfOH / CH₂Cl₂ / 20 h / Heating

7: H₂ / Pd/C / methanol / 3 h / 20 °C

With pyridine; trifluorormethanesulfonic acid; hydrogen; pyridinium p-toluenesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1039/b210503a