1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane

Base Information

• Chemical Name: 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane
• CAS No.: 163799-47-1
• Molecular Formula: C₂₉H₄₉NO₂Si₂
• Molecular Weight: 499.885
• Mol file: 163799-47-1.mol

Synonyms:1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane

Chemical Property of 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane

There total 6 articles about 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{4-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-benzyl}-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine → 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane (163799-47-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; diethyl ether; hexane; Yield given; Ambient temperature;

DOI:10.1021/jo00102a047

Reference yield:

4-(1-hydroxyethyl)benzonitrile (101219-69-6,101219-71-0,134679-06-4,52067-35-3) → 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane (163799-47-1)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 6 h / Ambient temperature

2: 1 M DIBALH / diethyl ether; hexane / 3 h / -80 °C

3: methanol; diethyl ether; hexane / 1.5 h / Ambient temperature

4: NaBH₄ / methanol; diethyl ether; hexane / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; diisobutylaluminium hydride; In methanol; diethyl ether; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jo00102a047

Reference yield:

(R)-1-[(tert-butyldimethylsilyl)oxy-1-phenylethan-2-yl]amine (88044-21-7) → 1-<(tert-Butyldimethylsilyl)oxy>-2-<4-<1-((tert-butyldimethylsilyl)oxy)ethyl>benzylamino>-1-phenylethane (163799-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; diethyl ether; hexane / 1.5 h / Ambient temperature

2: NaBH₄ / methanol; diethyl ether; hexane / Ambient temperature

With sodium tetrahydroborate; In methanol; diethyl ether; hexane;

DOI:10.1021/jo00102a047

upstream raw materials:

4-(1-hydroxyethyl)benzonitrile

(R)-1-[(tert-butyldimethylsilyl)oxy-1-phenylethan-2-yl]amine

tert-butyldimethylsilyl chloride

4-<1-<(tert-Butyldimethylsilyl)oxy>ethyl>benzonitrile