1-Benzofuran-2-yl(piperidin-1-yl)methanone

Base Information

• Chemical Name: 1-Benzofuran-2-yl(piperidin-1-yl)methanone
• CAS No.: 77509-75-2
• Molecular Formula: C14H15 N O2
• Molecular Weight: 229.27
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50356125
• Wikidata: Q82135307
• Mol file: 77509-75-2.mol

Synonyms:77509-75-2;1-benzofuran-2-yl(piperidin-1-yl)methanone;Methanone,2-benzofuranyl-1-piperidinyl-;Benzofuran-2-yl(piperidin-1-yl)methanone;2-benzofuranyl(1-piperidinyl)methanone;1-(1-benzofuran-2-ylcarbonyl)piperidine;Oprea1_501113;SCHEMBL19864572;DTXSID50356125;STK899151;1-(2-Benzofuranylcarbonyl)-piperidine;AKOS002205380;1-(2-benzo[b]furanylcarbonyl)piperidine;1-(1-benzo[b]furan-2-carbonyl)piperidine;(1-Benzofuran-2-yl)(piperidin-1-yl)methanone;A839119;SR-01000014713;SR-01000014713-1

Chemical Property of 1-Benzofuran-2-yl(piperidin-1-yl)methanone

Chemical Property:

• PSA: 33.45000
• LogP: 2.99680
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 229.110278721
• Heavy Atom Count: 17
• Complexity: 286

Purity/Quality:

97% ^*data from raw suppliers

1-(1-BENZOFURAN-2-YLCARBONYL)PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C2=CC3=CC=CC=C3O2

Technology Process of 1-Benzofuran-2-yl(piperidin-1-yl)methanone

There total 7 articles about 1-Benzofuran-2-yl(piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

piperidine (110-89-4) + Benzofuran-2-carboxylic acid (496-41-3) → benzofuran-2-yl(piperidin-1-yl)methanone (77509-75-2)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.joc.1c00931

Reference yield: 80.0%

piperidine (110-89-4) + 3-chloro-2H-chromen-2-one (92-45-5) → benzofuran-2-yl(piperidin-1-yl)methanone (77509-75-2)

Guidance literature:

Ambient temperature;

DOI:10.1002/jhet.5570180122

Reference yield: 76.0%

piperidine (110-89-4) + 2-(β,β-dibromovinyl)phenol (91703-34-3) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → benzofuran-2-yl(piperidin-1-yl)methanone (77509-75-2)

Guidance literature:

With 1,10-Phenanthroline; copper dichloride; In propan-1-ol; at 100 ℃; for 8h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c01620

upstream raw materials:

piperidine

2-benzofuroyl chloride

3-chloro-2H-chromen-2-one

3-bromo-2H-chromen-2-one

Downstream raw materials:

2-(2-hydroxybenzoyl)benzofuran