(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

Base Information

Chemical Name:(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide
CAS No.:1255928-54-1
Molecular Formula:C₂₄H₃₂N₂O₃
Molecular Weight:396.53
Hs Code.:

Synonyms:(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

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Chemical Property of (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

Chemical Property:

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Technology Process of (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

There total 5 articles about (E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-10-8,42939-71-9
propylamine

: 1255928-51-8
(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoic acid

: 1255928-54-1
(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

Guidance literature:: With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja104999v

Reference yield:

: 1255928-47-2
3-(dimethylamino)-5-(ethoxycarbonyl)benzoic acid

: 1255928-54-1
(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Reflux

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

3.1: triethyl phosphite / 3 h / 150 °C

3.2: 18 h / 0 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

5.1: dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

With dmap; N-chloro-succinimide; 1-hydroxy-7-aza-benzotriazole; borane-THF; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1255928-48-3
ethyl 3-(dimethylamino)-5-(hydroxymethyl)benzoate

: 1255928-54-1
(E)-3-(dimethylamino)-5-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

2.1: triethyl phosphite / 3 h / 150 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

4.1: dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

With dmap; N-chloro-succinimide; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; triethyl phosphite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;