4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

Base Information

Chemical Name:4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether
CAS No.:209688-45-9
Molecular Formula:C₁₅H₁₄ClNO₃
Molecular Weight:291.734
Hs Code.:

Synonyms:4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

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Chemical Property of 4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

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Technology Process of 4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

There total 5 articles about 4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 209688-14-2
methyl 4-[(5-chloro-2-nitrobenzyl)oxy]benzoate

: 209688-45-9
4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

Guidance literature:: With hydrogen; In methanol; at 20 ℃; for 2h; under 760.051 Torr; chemoselective reaction;
DOI:10.1016/j.tet.2015.10.037

Reference yield:

: 209688-14-2
methyl 4-[(5-chloro-2-nitrobenzyl)oxy]benzoate

: 7439-89-6
iron

: 209688-45-9
4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 209688-45-9
4-methoxycarbonylphenyl 5-chloro-2-aminobenzyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

2: 600 mg / Et₃N / CH₂Cl₂ / 0.25 h / -10 °C

3: 464 mg / K₂CO₃ / acetone / 22 h / 20 °C

4: HCl; Fe / tetrahydrofuran; H₂O / 96 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; iron; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2006.04.038