benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

Base Information

Chemical Name:benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate
CAS No.:318499-01-3
Molecular Formula:C₃₇H₅₀N₂O₆Si
Molecular Weight:646.899
Hs Code.:

Synonyms:benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

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Chemical Property of benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

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Technology Process of benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

There total 1 articles about benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1738-69-8
L-Leucine benzyl ester

: 63219-70-5
N-(benzyloxycarbonyl)-D-phenylalaninal

: 128302-78-3
α-(tert-butyldimethylsilyloxy)malonitrile

: benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

: 318499-01-3
benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

Guidance literature:: With 4-pyrrolidin-1-ylpyridine; In diethyl ether; at 0 ℃; for 5h;
DOI:10.1021/ol006816m

Reference yield: 96.0%

: 318499-01-3
benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

: 60016-66-2
benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1021/ol006816m

Reference yield:

: 318499-01-3
benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate

: 65391-42-6,100992-60-7
Bestatin hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C

2: H₂ / Pd/C / methanol / 2 h / atmospheric pressure

With tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/ol006816m