63219-70-5

Basic information

• Product Name: CBZ-D-PHENYLALANINAL
• Synonyms: CBZ-D-PHENYLALANINAL;(R)-(+)-2-(Benzylcarbonylamino)-3-phenylpropanal;(R)-Benzyl (1-oxo-3-phenylpropan-2-yl)carbamate
• CAS NO: 63219-70-5
• Molecular Formula: C₁₇H₁₇NO₃
• Molecular Weight: 283.32178
• Mol File: 63219-70-5.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 482.266 °C at 760 mmHg
• Flash Point: 183.494 °C
• Appearance: /
• Density: 1.168
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: CBZ-D-PHENYLALANINAL(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-D-PHENYLALANINAL(63219-70-5)
• EPA Substance Registry System: CBZ-D-PHENYLALANINAL(63219-70-5)

Safety Data

• Hazardous Substances Data: 63219-70-5(Hazardous Substances Data)

Usage

General Description

CBZ-D-PHENYLALANINAL, also known as N-CBZ-D-phenylalaninal, is a chemical compound used in the synthesis of pharmaceuticals and organic compounds. It is a derivative of the amino acid phenylalanine, and is commonly used as a chiral auxiliary in organic synthesis. The "CBZ" in its name stands for carbobenzyloxy, indicating the presence of a benzyl group attached to the amino group of phenylalanine. This chemical is widely used in the production of various pharmaceuticals and is an important building block in the field of medicinal chemistry and drug development.

Upstream product

• 42998-44-7 rac-N-benzyloxycarbonyl-phenylalanine ethyl ester 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 1217341-14-4 C₁₈H₂₃NO₂ 
• 1084820-37-0 1,1-dimethoxy-3-phenylpropan-2-one oxime 
• 94234-87-4 C₁₇H₁₈Se 
• 31139-36-3 dibenzyl dicarbonate 
• 673-06-3 D-(R)-phenylalanine 
• 41518-17-6 C₂₂H₂₅NO₆ 
• 37440-07-6 methyl (R)-2-(benzyloxycarbonylamino)-3-phenylpropanoate 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 2448-45-5 Cbz-D-Phe 
• 120452-49-5 N-methoxy-N-methyl-(R)-N²-Cbz-phenylalaninamide 
• 58917-85-4 N-(benzyloxycarbonyl)-D-phenylalaninol 

Downstream Products

• 175776-24-6 (Z)-(R)-4-Benzyloxycarbonylamino-5-phenyl-pent-2-enoic acid methyl ester 
• 221207-59-6 (1S,3R,4R)-3-Benzyloxy-1-((1R,2R,3R)-3-benzyloxycarbonylamino-1,2-dihydroxy-4-phenyl-butyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester 
• 153223-10-0 (2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol 
• 249296-51-3 (+/-)-3-[(Benzyloxycarbonyl)amino]-4-phenylbutan-2-ol 
• 301544-46-7 (S)-2-((R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester 
• 130405-00-4 4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid,ethyl ester 
• 13326-10-8 benzyl methyl carbonate 
• 144676-39-1 (1-Benzyl-2-cyano-2-trimethylsilanyloxy-ethyl)-carbamic acid benzyl ester 
• 144676-39-1 ((R)-1-Benzyl-2-cyano-2-trimethylsilanyloxy-ethyl)-carbamic acid benzyl ester 
• 68437-25-2 7c-benzyl-5,6t-dimethyl-1,9-dioxo-(3ar,6ac,9acC¹)-3a,6,6a,7-tetrahydro-3H-furo[3,4-d]isoindole-8-carboxylic acid benzyl ester 

Relevant articles and documents

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides

Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to the ide

Resolution and absolute configuration of some a-aminoacetals: En route to enantiopure N-protected a-aminoaldehydes

The first successful resolution of rac-a-aminoacetals via diastereoisomeric salt formation with optically pure N-protected aminoacids is reported. The absolute configuration assignment of a-aminoacetal enantiomers is performed by an entirely non-racemizing chemical correlation method involving N-protection and a new efficient hydrolysis step followed by a reduction of the resulting N-protected a-aminoaldehyde intermediates. A racemization method of optically enriched a-aminoacetals is exemplified to allow valorisation of both enantiomers. Springer-Verlag 2011.

A novel and efficient synthesis of chiral C2-symmetric 1,4-diamines

A novel and efficient method for synthesis of (R,R)- and (S,S)-C2-symmetric 1,4-diamines was established. The key steps are a combination of Pinacol Coupling and Corey-Winter olefination.