(1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester

Base Information

• Chemical Name: (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester
• CAS No.: 221207-57-4
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.445

Synonyms:(1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester

Chemical Property of (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester

There total 3 articles about (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester (221207-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 2.5 h / Ambient temperature

2: LiBH₄ / diethyl ether / 15 h / Ambient temperature

With lithium borohydride; sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00659-3

Reference yield:

(1S,3R,4R)-3-Hydroxy-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester (182137-84-4) → (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester (221207-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 2.5 h / Ambient temperature

2: LiBH₄ / diethyl ether / 15 h / Ambient temperature

With lithium borohydride; sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00659-3

Reference yield:

(1S,3R,4R)-3-Benzyloxy-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester → (1S,3R,4R)-3-Benzyloxy-1-hydroxymethyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester (221207-57-4)

Guidance literature:

With lithium borohydride; In diethyl ether; for 15h; Yield given; Ambient temperature;

DOI:10.1016/S0960-894X(98)00659-3

upstream raw materials:

benzyl bromide

(1S,3R,4R)-3-Hydroxy-7-aza-bicyclo[2.2.1]heptane-1,7-dicarboxylic acid 7-benzyl ester 1-tert-butyl ester

Downstream raw materials:

C₄₁H₅₂N₄O₅Si

(1S,3R,4R)-3-Benzyloxy-1-((1R,2R,3R)-3-benzyloxycarbonylamino-1,2-dihydroxy-4-phenyl-butyl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester

C₂₇H₃₂N₂O₄

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