(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

Base Information

Chemical Name:(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide
CAS No.:1071504-78-3
Molecular Formula:C₁₅H₁₅N₃O
Molecular Weight:253.304
Hs Code.:

Synonyms:(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

Chemical Property:

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Technology Process of (R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

There total 1 articles about (R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1071504-65-8
10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 17199-29-0
(S)-Mandelic acid

: 1071504-78-3
(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 1071504-77-2
(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

Guidance literature:: 10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide; (S)-Mandelic acid; In ethanol; at 20 - 65 ℃; for 24h; Resolution of racemate;

With sodium carbonate; In water; Purification / work up;

Reference yield: 39.0%

: 1071504-78-3
(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 611-71-2
(R)-Mandelic Acid

: (R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (-)-(R)-mandelic acid salt

Guidance literature:: In ethanol; at 20 ℃; Purification / work up;

Reference yield:

: 1071504-78-3
(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 61337-67-5,61364-37-2
(-)-Mirtazapine

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0.08 h / 0 °C

1.2: 18 h / 0 - 20 °C

1.3: 20 h / 20 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / Heating / reflux

3.1: thionyl chloride / dichloromethane / 0.25 h / 20 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C / Heating / reflux

With thionyl chloride; boron trifluoride diethyl etherate; potassium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;