(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

Base Information

Chemical Name:(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt
CAS No.:1071504-77-2
Molecular Formula:C₈H₈O₃*C₁₅H₁₅N₃O
Molecular Weight:405.453
Hs Code.:

Synonyms:(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

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Chemical Property of (S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

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Technology Process of (S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

There total 5 articles about (S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1071504-65-8
10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 17199-29-0
(S)-Mandelic acid

: 1071504-78-3
(R)-(-)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 1071504-77-2
(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

Guidance literature:: 10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide; (S)-Mandelic acid; In ethanol; at 20 - 65 ℃; for 24h; Resolution of racemate;

With sodium carbonate; In water; Purification / work up;

Reference yield: 31.0%

: 1071504-65-8
10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide

: 17199-29-0
(S)-Mandelic acid

: 1071504-77-2
(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

Guidance literature:: In ethanol; at 20 - 65 ℃; for 24h; Purification / work up;

Reference yield:

: 130277-16-6
2-amino-3-benzylpyridine

: 1071504-77-2
(S)-(+)-10,11-dihydro-5H-benzo[e]pyrido[2,3-b]azepine-10-N-methylcarboxamide (+)-(S)-mandelic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 0.5 h / 20 °C

2: water / 20 - 65 °C / Heating / reflux

3: ethanol / 24 h / 20 - 65 °C

sulfuric acid; In ethanol; water;