[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

Base Information

Chemical Name:[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid
CAS No.:1310038-49-3
Molecular Formula:C₂₃H₂₁F₂NO₄
Molecular Weight:413.421
Hs Code.:

Synonyms:[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

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Chemical Property of [3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

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Technology Process of [3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

There total 6 articles about [3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1310218-55-3
C₂₅H₂₅F₂NO₄

: 1310038-49-3
[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran;
DOI:10.1039/c3md00053b

Reference yield:

: 1310036-75-9
[3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)benzylamino]-acetic acid ethyl ester hydrochloride

: 1310038-49-3
[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

Guidance literature:: [3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)benzylamino]-acetic acid ethyl ester hydrochloride; With lithium hydroxide; In tetrahydrofuran; for 3h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 870777-32-5
(4,5-difluoro-2-methoxyphenyl)boronic acid

: 1310038-49-3
[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 15 h / 60 °C

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 15 h / Reflux

4: lithium hydroxide; water / tetrahydrofuran

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3md00053b