2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

Base Information

Chemical Name:2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide
CAS No.:1184931-44-9
Molecular Formula:C₂₇H₃₁N₅O₄
Molecular Weight:489.574
Hs Code.:

Synonyms:2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

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Chemical Property of 2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

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Technology Process of 2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

There total 4 articles about 2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 209960-91-8
2-methoxy-4-morpholinoaniline

: 1184931-58-5
2-(2-chloro-5-cyclopropyl-pyridin-4-ylamino)-N-methoxy-benzamide

: 1184931-44-9
2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 0.5h; Inert atmosphere; microwave irradiation;

Reference yield:

: 118-48-9
isatoic anhydride

: 1184931-44-9
2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol; water / 4 h / Reflux

2: potassium phosphate / palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / Inert atmosphere; Reflux

3: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / 100 °C / Inert atmosphere; tube sealed

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; microwave irradiation

With potassium fluoride; potassium phosphate; caesium carbonate; triethylamine; sodium bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 1184931-57-4
2-(5-bromo-2-chloro-pyridin-4-ylamino)-N-methoxy-benzamide

: 1184931-44-9
2-[5-cyclopropyl-2-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyridin-4-ylamino]-N-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / 100 °C / Inert atmosphere; tube sealed

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; microwave irradiation

With potassium fluoride; caesium carbonate; sodium bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; toluene;