2-[(2-chloro-5-cyclopropyl-4-pyridinyl)amino]-N-methoxybenzamide

Base Information

Chemical Name:2-[(2-chloro-5-cyclopropyl-4-pyridinyl)amino]-N-methoxybenzamide
CAS No.:1184931-58-5
Molecular Formula:C₁₆H₁₆ClN₃O₂
Molecular Weight:317.775
Hs Code.:
Mol file:1184931-58-5.mol

Synonyms:2-[(2-chloro-5-cyclopropyl-4-pyridinyl)amino]-N-methoxybenzamide

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Chemical Property of 2-[(2-chloro-5-cyclopropyl-4-pyridinyl)amino]-N-methoxybenzamide

Chemical Property:

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Technology Process of 2-[(2-chloro-5-cyclopropyl-4-pyridinyl)amino]-N-methoxybenzamide

There total 3 articles about 2-[(2-chloro-5-cyclopropyl-4-pyridinyl)amino]-N-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1184931-57-4
2-(5-bromo-2-chloro-pyridin-4-ylamino)-N-methoxy-benzamide

: 411235-57-9
cyclopropylboronic acid

: 1184931-58-5
2-(2-chloro-5-cyclopropyl-pyridin-4-ylamino)-N-methoxy-benzamide

Guidance literature:: With potassium fluoride; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 100 ℃; for 24h; Sealed tube;

Reference yield:

: 118-48-9
isatoic anhydride

: 1184931-58-5
2-(2-chloro-5-cyclopropyl-pyridin-4-ylamino)-N-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol; water / 4 h / Reflux

2: potassium phosphate / palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / Inert atmosphere; Reflux

3: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / 100 °C / Inert atmosphere; tube sealed

With potassium fluoride; potassium phosphate; triethylamine; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 40928-15-2
2-amino-N-methoxy-benzamide

: 1184931-58-5
2-(2-chloro-5-cyclopropyl-pyridin-4-ylamino)-N-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / Inert atmosphere; Reflux

2: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 24 h / 100 °C / Inert atmosphere; tube sealed

With potassium fluoride; potassium phosphate; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; water; toluene;