methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate

Base Information

• Chemical Name: methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate
• CAS No.: 1383812-73-4
• Molecular Formula: C₃₄H₂₈N₄O₃
• Molecular Weight: 540.621
• Mol file: 1383812-73-4.mol

Synonyms:methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate

Chemical Property of methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate

There total 9 articles about methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-(3-amino-2-(1H-indol-1-yl)phenyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate (1383811-81-1) + benzaldehyde (100-52-7) → methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate (1383812-73-4)

Guidance literature:

With magnesium sulfate; trifluoroacetic acid; In chloroform; for 14h; Reflux; Inert atmosphere;

DOI:10.1002/asia.201200121

Reference yield:

methyl 2-(2-(1H-indol-1-yl)-3-nitrophenyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate (1383811-78-6) → methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate (1383812-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium formate; zinc / methanol / 0.17 h / 20 °C / Inert atmosphere

2: magnesium sulfate; trifluoroacetic acid / chloroform / 14 h / Reflux; Inert atmosphere

With ammonium formate; magnesium sulfate; trifluoroacetic acid; zinc; In methanol; chloroform; 2: Pictet-Spengler-type cyclization reaction;

DOI:10.1002/asia.201200121

Reference yield:

methyl 2-(2-(indolin-1-yl)-3-nitrophenyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate (1383811-72-0) → methyl 1-(3-methoxypropyl)-2-(6-phenylindolo[1,2-a]quinoxalin-1-yl)-1H-benzimidazole-5-carboxylate (1383812-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: ammonium formate; zinc / methanol / 0.17 h / 20 °C / Inert atmosphere

3: magnesium sulfate; trifluoroacetic acid / chloroform / 14 h / Reflux; Inert atmosphere

With ammonium formate; magnesium sulfate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In methanol; dichloromethane; chloroform; 3: Pictet-Spengler-type cyclization reaction;

DOI:10.1002/asia.201200121

upstream raw materials:

methyl 3-(2-chloro-3-nitrobenzamido)-4-((3-methoxypropyl)amino)benzoate

methyl 2-(2-chloro-3-nitrophenyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

methyl 2-(2-(indolin-1-yl)-3-nitrophenyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

methyl 2-(2-(1H-indol-1-yl)-3-nitrophenyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate