(+)-PPM

Base Information

Chemical Name:(+)-PPM
CAS No.:77450-05-6
Molecular Formula:C29H29 N P2
Molecular Weight:453.49
Hs Code.:2933990090
Mol file:77450-05-6.mol

Synonyms:Pyrrolidine,4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]-, (2R-cis)-

Suppliers and Price of (+)-PPM

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
(2R,4R)-(+)-2-(Diphenylphosphinomethyl)-4-(diphenylphosphino)pyrrolidine, min. 97% (R,R-PPM)
100mg
$ 118.00

Strem Chemicals
(2R,4R)-(+)-2-(Diphenylphosphinomethyl)-4-(diphenylphosphino)pyrrolidine, min. 97% (R,R-PPM)
500mg
$ 471.00

BLDpharm
(2R,4R)-(+)-2-(Diphenylphosphinomethyl)-4-(diphenylphosphino)pyrrolidine 98%
50mg
$ 130.00

Arctom
(2R,4R)-(+)-2-(Diphenylphosphinomethyl)-4-(diphenylphosphino)pyrrolidine 98%
100mg
$ 230.00

Arctom
(2R,4R)-(+)-2-(Diphenylphosphinomethyl)-4-(diphenylphosphino)pyrrolidine 98%
50mg
$ 129.00

American Custom Chemicals Corporation
(2R,4R)-(+)-4-DIPHENYL PHOSPHINO2-DIPHENYLPHOSPHINO METHYLPYRROLIDINE 95.00%
5MG
$ 498.17

Total 3 raw suppliers

Chemical Property of (+)-PPM

Chemical Property:

Boiling Point:575.8±35.0 °C(Predicted)
PKA:9.87±0.10(Predicted)
PSA：39.21000
LogP:5.31150
Sensitive.:air sensitive

Purity/Quality:

97% ^*data from raw suppliers

(2R,4R)-(+)-2-(Diphenylphosphinomethyl)-4-(diphenylphosphino)pyrrolidine, min. 97% (R,R-PPM) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (+)-PPM

There total 11 articles about (+)-PPM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 72598-03-9
N-(tert-Butoxycarbonyl)-(2R,4R)-4-(diphenylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine

: 77450-05-6
(2R,4R)-4-(Diphenylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine

Guidance literature:: With trifluoroacetic acid;
DOI:10.1021/jo00327a023

Reference yield:

: 77449-99-1
(2R,4R)-2-ethoxycarbonyl-4-hydroxypyrrolidine hydrochloride

: 77450-05-6
(2R,4R)-4-(Diphenylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / Et₃N / dioxane; H₂O / 15 h / 50 °C

2: 89 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h

3: 1.) Et₄NOAc*4H₂O, 2.) 1 N NaOH / 1.) benzene, reflux, 1.5 h, 2.) MeOH, 0 deg C

4: 45 percent / LiBH₄ / tetrahydrofuran

5: 69 percent / pyridine

6: 34 percent / 1.) Na/NH₃ (liq.) / tetrahydrofuran

7: 87 percent / CF₃COOH

With sodium hydroxide; lithium borohydride; tetraethylammonium acetate; ammonia; sodium; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; water;
DOI:10.1021/jo00327a023

Reference yield:

: 77449-94-6,441067-49-8
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride

: 77450-05-6
(2R,4R)-4-(Diphenylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / HCl (gas) / 5 h / Heating

2: 87 percent / Et₃N / dioxane; H₂O / 15 h / 50 °C

3: 89 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h

4: 1.) Et₄NOAc*4H₂O, 2.) 1 N NaOH / 1.) benzene, reflux, 1.5 h, 2.) MeOH, 0 deg C

5: 45 percent / LiBH₄ / tetrahydrofuran

6: 69 percent / pyridine

7: 34 percent / 1.) Na/NH₃ (liq.) / tetrahydrofuran

8: 87 percent / CF₃COOH

With hydrogenchloride; sodium hydroxide; lithium borohydride; tetraethylammonium acetate; ammonia; sodium; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; water;
DOI:10.1021/jo00327a023