72598-03-9 Usage
Uses
Used in Organic Synthesis:
(2R,4R)-BPPM is used as a chiral building block for the synthesis of various organic compounds. Its unique configuration allows for the creation of enantioselective reactions, which are crucial in producing specific enantiomers of chiral molecules with desired biological activities.
Used in Catalysis:
(2R,4R)-BPPM serves as a chiral catalyst in asymmetric catalysis, enabling the selective formation of one enantiomer over another in chemical reactions. This selective catalysis is essential in producing enantiomerically pure compounds, which are often required for pharmaceutical and agrochemical applications.
Used in Medicinal Chemistry:
(2R,4R)-BPPM is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly those with chiral centers. Its unique configuration can contribute to the development of new drugs with improved efficacy, selectivity, and reduced side effects.
Used in Chemical Research:
(2R,4R)-BPPM is utilized as a research tool in studying the properties and reactivity of chiral phosphorus compounds. Its use in various chemical reactions helps to advance the understanding of stereochemistry and the role of chirality in chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 72598-03-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,9 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 72598-03:
(7*7)+(6*2)+(5*5)+(4*9)+(3*8)+(2*0)+(1*3)=149
149 % 10 = 9
So 72598-03-9 is a valid CAS Registry Number.
72598-03-9Relevant academic research and scientific papers
Transition-Metal-Catalyzed Asymmetric Organic Synthesis via Polymer-Attached Optically Active Phosphine Ligands. 5. Preparation of Amino Acids in High Optical Yield via Catalytic Hydrogenation
Baker, Gregory L.,Fritschel, Scott J.,Stille, John R.,Stille, John K.
, p. 2954 - 2960 (2007/10/02)
Two new optically active phosphinopyrrolidine monomers were prepared by the reaction of (2S,4S)-4-(diphenylphosphino)-2-pyrrolidine and (2R,4R)-4-(diphenylphosphino)-2-pyrrolidine with acryloyl chloride to give N-acryloyl-(2S,4S)-4-(diphenylphosphino)-2-pyrrolidine (1) and N-acryloyl-(2R,4R)-4-(diphenylphosphino)-2-pyrrolidine (2).Copolymerization of 1 and 2 with hydrophilic comonomers and a divinyl monomer provided cross-linked insoluble polymers containing 3-5percentof 1 or 2 that would swell in polar solvents.Exchange of rhodium (I) onto the polymer gave catalysts which were active for the asymmetric hydrogenation of N-acyl α-amino acids in high optical yields, the phosphine derived from the enantiomer of the naturally occurring 4-hydroxyproline giving (S)-amino acids.The catalysts could be reused with no loss in selectivity by simple filtration.
