(2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
CAS No.:77449-97-9
Molecular Formula:C₇H₁₁NO₄
Molecular Weight:173.169
Hs Code.:2933990090
European Community (EC) Number:882-039-0
Mol file:77449-97-9.mol

Synonyms:(2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid;106564-72-1;77449-97-9;D-Proline, 1-acetyl-4-hydroxy-, (4S)-rel- (9CI);SCHEMBL3780150;AKOS026744790;EN300-158274;EN300-28271147;Z1262515248;rac-(2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid;rel-(2R,4S)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid;rel-(2R,4S)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylicacid

Suppliers and Price of (2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylicacid
10mg
$ 45.00

Total 3 raw suppliers

Chemical Property of (2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid

Chemical Property:

PSA：77.84000
LogP:-1.00940
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:173.06880783
Heavy Atom Count:12
Complexity:216

Purity/Quality:

99% ^*data from raw suppliers

(2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CC(CC1C(=O)O)O
Isomeric SMILES:CC(=O)N1C[C@H](C[C@@H]1C(=O)O)O

Technology Process of (2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid

There total 9 articles about (2R,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 33996-33-7,37712-75-7,66267-44-5,77449-97-9,106564-72-1
cis-1-acetyl-4-hydroxy-DL-proline

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; concentrated aqueous hydrochloric acid; sulfuryl chloride

2: aqueous NH₃ / 100 °C

3: acetic acid

With hydrogenchloride; ammonium hydroxide; sulfuryl dichloride; acetic acid;
DOI:10.1021/ja01630a038

Reference yield:

: 2584-72-7
3-chloro-5-chloromethyl-dihydro-furan-2-one

: 33996-33-7,37712-75-7,66267-44-5,77449-97-9,106564-72-1
cis-1-acetyl-4-hydroxy-DL-proline

Guidance literature:: Multi-step reaction with 2 steps

1: aqueous NH₃ / 100 °C

2: acetic acid

With ammonium hydroxide; acetic acid;
DOI:10.1021/ja01630a038

Reference yield:

: 854657-58-2
3-bromo-5-chloromethyl-dihydro-furan-2-one

: 33996-33-7,37712-75-7,66267-44-5,77449-97-9,106564-72-1
cis-1-acetyl-4-hydroxy-DL-proline

Guidance literature:: Multi-step reaction with 2 steps

1: aqueous NH₃ / 100 °C

2: acetic acid

With ammonium hydroxide; acetic acid;
DOI:10.1021/ja01630a038