N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

Base Information

Chemical Name:N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester
CAS No.:100431-53-6
Molecular Formula:C₁₇H₂₄N₂O₄
Molecular Weight:320.389
Hs Code.:

Synonyms:N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

There total 3 articles about N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 100431-52-5
N-<(R,S)-2-carboxy-1-oxopropyl>-L-phenyl alanine tert-butyl ester

: 100431-53-6
N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; ammonia; dicyclohexyl-carbodiimide; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00155a027

Reference yield:

: 16874-17-2
L-phenylalanine tert-butyl ester

: 100431-53-6
N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CHCl₃; tetrahydrofuran / Ambient temperature

2: 80 percent / 1N aq. NaOH / ethanol / 2 h / Ambient temperature

3: 82 percent / N-hydroxysuccinimide, N,N'-dicyclohexylcarbodiimide, NH₃ / tetrahydrofuran / Ambient temperature

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; ammonia; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00155a027

Reference yield:

: 100431-51-4
N-<(R,S)-2-(ethoxycarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

: 100431-53-6
N-<(R,S)-2-(aminocarbonyl)-1-oxopropyl>-L-phenyl alanine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1N aq. NaOH / ethanol / 2 h / Ambient temperature

2: 82 percent / N-hydroxysuccinimide, N,N'-dicyclohexylcarbodiimide, NH₃ / tetrahydrofuran / Ambient temperature

With sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; ammonia; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00155a027