3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

Base Information

Chemical Name:3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone
CAS No.:134458-54-1
Molecular Formula:C₃₀H₄₄N₂O₇
Molecular Weight:544.689
Hs Code.:

Synonyms:3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

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Chemical Property of 3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

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Technology Process of 3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

There total 1 articles about 3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107600-00-0
3-<3(R)-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isopropyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: 134458-54-1
3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.333333h;
DOI:10.1021/jm00112a005

Reference yield: 60.0%

: 134458-54-1
3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: 107600-00-0
3-<3(R)-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isopropyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: 134527-85-8
3-<3(S)-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-isopropyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.25h;
DOI:10.1021/jm00112a005

Reference yield:

: 134458-54-1
3-<3-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-isobutyl-5(R)-oxazolidinyl>-2(R)-isopropyl-1,3-dioxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: 4-[(S)-2-((1S,2R,3R,4R)-2,3-Dihydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexylcarbamoyl)-2-(2-phenoxy-acetylamino)-ethyl]-imidazole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / sodium borohydride / methanol / 0.25 h / 0 °C

3: periodic acid, ruthenium trichloride hydrate / acetonitrile; CCl₄; H₂O / 2 h

4: 1.) camphorsulfonic acid, 2.) acetone / 1.) CH₂Cl₂, RT, 45 min, 2.) CH₂Cl₂, RT, 14 h

5: diisopropylethylamine, diethylphosphoryl cyanide / CH₂Cl₂ / 14 h / Ambient temperature

6: acetyl chloride, ethanedithiol / methanol / 5 h

7: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 14 h

With ethandithiol; ruthenium trichloride; sodium tetrahydroborate; diethylphosphoryl cyanide; camphor-10-sulfonic acid; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; periodic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; acetone; In methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00112a005