107600-00-0Relevant academic research and scientific papers
Inhibitors of the Protease from Human Immunodeficiency Virus: Design and Modeling of a Compound Containing a Dihydroxyethylene Isostere Insert with High Binding Affinity and Effective Antiviral Activity
Thaisrivongs, Suvit,Tomasselli, Alfredo G.,Moon, Joseph B.,Hui, John,McQuade, Thomas J.,et al.
, p. 2344 - 2356 (2007/10/02)
The peptidomimetic template and the dihydroxyethylene isostere insert that were applied successfully to the design of renin inhibitors have been extended to the related protease from human immunodeficiency virus (HIV).The present report describes the stru
Renin Inhibitors. Design of Angiotensinogen Transition-State Analogues Containing Novel (2R,3R,4R,5S)-5-Amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic Acid
Thaisrivongs, Suvit,Pals, Donald T.,Kroll, Lisa T.,Turner, Steve R.,Han, Fu-Son
, p. 976 - 982 (2007/10/02)
A highly stereoselective synthesis of 2(R)--3-methylbutyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid (11) is described.This is a suitably protected carboxylic acid useful as an intermediate for the prepa
