6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

Base Information

Chemical Name:6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione
CAS No.:134755-35-4
Molecular Formula:C₂₄H₂₉Br₂N₃O₅Si
Molecular Weight:627.405
Hs Code.:

Synonyms:6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

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Chemical Property of 6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

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Technology Process of 6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

There total 14 articles about 6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 73414-58-1
2-(3,5-dibromo-4-hydroxyphenyl)ethan-1-amine hydrobromide

: 134755-33-2
6-methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

: 134755-35-4
6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

Guidance literature:: With diisopropylamine; In ethanol; for 48h; Heating;

Reference yield: 52.0%

: 134755-34-3
3,5-dibromo-4-hydroxy-β-phenethylamine

: [2-(6-Methoxy-4,7-dioxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-ethyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

: 134755-35-4
6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

Guidance literature:: In ethanol; Heating;
DOI:10.1016/S0040-4039(00)78901-5

Reference yield:

: 138518-16-8
4-benzyloxy-6-methoxy-1H-indole

: 134755-35-4
6-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole-4,7-dione

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) iodomethane / 1.) THF, from 0 deg C to 4 deg C, 30 h, 2.) water, 80 deg C, 3.5 h

3: H₂, NH₃ / Raney nickel / ethanol / 48 h / 2508 Torr / Ambient temperature

4: 1.) NaOEt / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, RT, 3 h

5: H₂ / 10percent Pd/C / ethanol / 48 h / 2508 Torr / Ambient temperature

6: Fremy's salt, aq. KH₂PO₄ / acetone / 4 h / 0 °C

7: 55 percent / diisopropylamine / ethanol / 48 h / Heating

With potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; ammonia; hydrogen; sodium ethanolate; acetic acid; diisopropylamine; methyl iodide; palladium on activated charcoal; nickel; In ethanol; dichloromethane; acetone;