3-QUINOLIN-8-YLACRYLIC ACID

Base Information

• Chemical Name: 3-QUINOLIN-8-YLACRYLIC ACID
• CAS No.: 77377-27-6
• Molecular Formula: C₁₂H₉NO₂
• Molecular Weight: 199.209
• Hs Code.: 2933499090
• Mol file: 77377-27-6.mol

Synonyms:8-Quinolineacrylicacid (6CI)

Chemical Property of 3-QUINOLIN-8-YLACRYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.712
• Boiling Point: 408.022°C at 760 mmHg
• Flash Point: 200.565°C
• PSA: 50.19000
• Density: 1.307g/cm³
• LogP: 2.33260

Purity/Quality:

98.5% ^*data from raw suppliers

(2E)-3-quinolin-8-ylacrylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-QUINOLIN-8-YLACRYLIC ACID

There total 4 articles about 3-QUINOLIN-8-YLACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (2E)-3-(quinolin-8-yl)prop-2-enoate → (2E)-3-(quinolin-8-yl)prop-2-enoic acid (77377-27-6)

Guidance literature:

methyl (2E)-3-(quinolin-8-yl)prop-2-enoate; With sodium hydroxide; In methanol; water; at 20 ℃; for 1.5h; Inert atmosphere;

With hydrogenchloride; In methanol; water; Inert atmosphere;

DOI:10.1002/open.201300031

Reference yield:

8-formylquinoline (38707-70-9) → (2E)-3-(quinolin-8-yl)prop-2-enoic acid (77377-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 72 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / water; methanol / 1.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium hydroxide; In methanol; dichloromethane; water; 1.1: |Wittig Olefination;

DOI:10.1002/open.201300031

Reference yield:

8-formylquinoline (38707-70-9) + malonic acid (141-82-2) → (2E)-3-(quinolin-8-yl)prop-2-enoic acid (77377-27-6)

Guidance literature:

With piperidine; pyridine;

DOI:10.1002/hlca.19550380614

upstream raw materials:

8-formylquinoline

malonic acid

Refernces

• 1、 Waehler, Kathrin,Kraeling, Katja,Steuber, Holger,Meggers, Eric. "Non-ATP-mimetic organometallic protein kinase inhibitor". . p. 180 - 185. Retrieved 2013.