8-Quinolinecarbaldehyde

Base Information

• Chemical Name: 8-Quinolinecarbaldehyde
• CAS No.: 38707-70-9
• Molecular Formula: C10H7 N O
• Molecular Weight: 157.172
• Hs Code.: 29334900
• Mol file: 38707-70-9.mol

Synonyms:8-Formylquinoline;8-Quinolinecarbaldehyde; Quinoline-8-carbaldehyde

Chemical Property of 8-Quinolinecarbaldehyde

Chemical Property:

• Vapor Pressure: 0.00047mmHg at 25°C
• Melting Point: 95-96 ºC
• Boiling Point: 314.3°C at 760 mmHg
• PKA: 3.45±0.17(Predicted)
• Flash Point: 151.9°C
• PSA: 29.96000
• Density: 1.223g/cm³
• LogP: 2.04730
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

Quinoline-8-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-36/38-43
• Safety Statements: 26-37/39-36/37

MSDS Files:

Useful:

• Uses: Quinoline-8-carboxaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Technology Process of 8-Quinolinecarbaldehyde

There total 2 articles about 8-Quinolinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-methoxylbenzylidene)benzylamine (622-72-0) + C16H13N3O3 → 8-formylquinoline (38707-70-9) + 5-(4-methoxy-benzylidene)-1,3-dimethyl-pyrimidine-2,4,6-trione (57270-82-3) + 4-methoxy-benzaldehyde (123-11-5)

Guidance literature:

With copper(II) ion; In [D₃]acetonitrile; at 24.84 ℃; Reagent/catalyst; Thermodynamic data;

DOI:10.1002/asia.202001001

Reference yield:

8-bromomethyl-quinoline (7496-46-0) → 8-formylquinoline (38707-70-9) + 8-hydroxymethylquinoline (16032-35-2)

Guidance literature:

With water; for 4h; Reflux;

DOI:10.1016/j.bmcl.2012.03.084

Reference yield: 93.0%

8-formylquinoline (38707-70-9) + 1,2-bis(4-methylphenyl)acetylene (2789-88-0) → C42H34BrNO

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) triflimide; In cyclohexane; at 100 ℃; for 16h; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/acscatal.6b01936

upstream raw materials:

8-bromomethyl-quinoline

N-(4-methoxylbenzylidene)benzylamine

Downstream raw materials:

4-[8]quinolylmethylenamino-benzoic acid butyl ester

(2E)-3-(quinolin-8-yl)prop-2-enoic acid

thiobenzoic acid-([8]quinolylmethylene-hydrazide)

4-[8]quinolylmethylenamino-phenol

Refernces

• 1、 Pokhrel, Laxman,Kim, Yunjeong,Nguyen, Thi D.T.,Prior, Allan M.,Lu, Jianyu,Chang, Kyeong-Ok,Hua, Duy H.. "Synthesis and anti-norovirus activity of pyranobenzopyrone compounds". supporting information; experimental part. p. 3480 - 3484. Retrieved 2012/07/03.