Technology Process of Z-Val-Thr(ψMe,Mepro)-Val-Thr(TBS)-OMe
There total 5 articles about Z-Val-Thr(ψMe,Mepro)-Val-Thr(TBS)-OMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 20 ℃;
DOI:10.1021/jo0484732
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / camphorsulfonic acid / CH2Cl2 / 5 h / 0 °C
2: 99 percent / aq. LiOH / methanol / 6 h / 20 °C
3: 97 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2; dimethylformamide / 0 - 20 °C
With
4-methyl-morpholine; lithium hydroxide; camphor-10-sulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0484732
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / imidazole / dimethylformamide / 36 h / 20 °C
2: H2 / Pd/C / methanol / 5 h
3: 97 percent / N-methylmorpholine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2; dimethylformamide / 0 - 20 °C
With
4-methyl-morpholine; 1H-imidazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0484732
