N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

Base Information

Chemical Name:N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide
CAS No.:1383854-09-8
Molecular Formula:C₃₄H₃₅N₃O₃S
Molecular Weight:565.736
Hs Code.:

Synonyms:N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

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Chemical Property of N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

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Technology Process of N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

There total 5 articles about N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1383852-20-7
4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-isopentylmethylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

: 14900-39-1
phenylvinylboronic acid

: 1383854-09-8
N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

Guidance literature:: With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; water; at 50 ℃; for 4h; Inert atmosphere; sealed tube;

Reference yield:

: 541-28-6
isopentyl iodide

: 1383854-09-8
N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 24 h

2: hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 6 h / 1551.49 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 1 h

4: potassium phosphate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran; water / 4 h / 50 °C / Inert atmosphere; sealed tube

With potassium phosphate; hydrogen; potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1383852-18-3
N-(2-(4-(benzyloxy)phenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)benzofuran-6-yl)-N-isopentylmethanesulfonamide

: 1383854-09-8
N-{5-cyclopropyl-3-(1H-imidazol-2-yl)-2-[4-(1-phenylvinyl)phenyl]-1-benzofuran-6-yl}-N-(3-methylbutyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 10 wt% Pd(OH)2 on carbon / N,N-dimethyl-formamide / 6 h / 1551.49 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 1 h

3: potassium phosphate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran; water / 4 h / 50 °C / Inert atmosphere; sealed tube

With potassium phosphate; hydrogen; potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; water; N,N-dimethyl-formamide;