(R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

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Chemical Name:(R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid
CAS No.:1310744-64-9
Molecular Formula:C₂₃H₂₀FN₃O₆S₂
Molecular Weight:517.559
Hs Code.:

Synonyms:(R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

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Chemical Property of (R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

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Technology Process of (R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

There total 6 articles about (R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1310744-61-6
(R,Z)-dimethyl 2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

: 1310744-64-9
(R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

Guidance literature:: (R,Z)-dimethyl 2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate; With lithium hydroxide; In methanol; water; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; water;
DOI:10.1021/jm2002525

Reference yield:

: 550363-85-4
2-fluoro-5-formyl-benzoic acid

: 1310744-64-9
(R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h

1.2: 3 h / 20 °C

2.1: acetic acid / methanol / 1 h / 65 °C

2.2: 24 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 16 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; lithium hydroxide; In methanol; dichloromethane; water;
DOI:10.1021/jm2002525

Reference yield:

: 4120-64-3
5-(4-nitrobenzylidene)-2-thioxothiazolidin-4-one

: 1310744-64-9
(R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

2.1: acetic acid / methanol / 1 h / 65 °C

2.2: 24 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 16 h / 20 °C

With tin(II) chloride dihdyrate; acetic acid; lithium hydroxide; In methanol; ethanol; water;
DOI:10.1021/jm2002525