550363-85-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Fluoro-5-formylbenzoic acid 95 is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional properties make it a valuable component in the development of new drugs and pesticides.
Used in Organic Chemistry Reactions:
As a reagent, 2-Fluoro-5-formylbenzoic acid 95 is employed in the modification of aromatic compounds. Its ability to participate in various organic reactions contributes to the synthesis of a wide range of organic molecules.
Used in Material Development:
2-Fluoro-5-formylbenzoic acid 95 is integral to the development of new materials. Its unique properties allow for the creation of innovative materials with potential applications in various industries.
Used in Research and Development:
2-Fluoro-5-formylbenzoic acid 95 is utilized in research and development for its catalytic and medicinal properties. Its potential applications in catalysis and medicine make it a valuable compound for scientific exploration and advancement.

InChI:InChI=1/C8H5FO3/c9-7-2-1-5(4-10)3-6(7)8(11)12/h1-4H,(H,11,12)

Upstream product

• 321-12-0 2-fluoro-5-methyl-benzoic acid 
• 201230-82-2 carbon monoxide 
• 227609-88-3 4-fluoro-3-iodobenzaldehyde 
• 218301-22-5 2-fluoro-5-formylbenzonitrile 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 165803-94-1 methyl 2-fluoro-5-formylbenzoate 

Downstream Products

• 1207454-81-6 2-fluoro-5-formyl-N,N-dimethylbenzamide 
• 1310744-61-6 (R,Z)-dimethyl 2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate 
• 1310744-63-8 (R,Z)-2-(5-(((4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)-2-fluorobenzamido)pentanedioic acid 
• 1310744-64-9 (R,Z)-2-(2-fluoro-5-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioic acid 
• 1310744-58-1 (R)-1,5-dimethyl 2-(2-fluoro-5-formylbenzamido)pentanedioate 
• 1334590-78-1 dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate 
• 1334590-84-9 (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioic acid 
• 1207454-80-5 2-Fluoro-N,N-dimethyl-5-(9-(1-methyl-1H-imidazol-2-yl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzamide 
• 1207454-82-7 (E)-2-fluoro-N,N-dimethyl-5-((1-oxo-1,3-dihydroisobenzofuran-4-ylimino)methyl)benzamide 
• 1207454-83-8 ethyl 2-(3-(dimethylcarbamoyl)-4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate 
• 1813527-81-9 4-(4-fluoro-3-((piridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-imidazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 

Relevant academic research and scientific papers

Pharmaceutical composition for use in preventing or treating poly(ADP-ribose)polymerase-1 related diseases containing the same as an active ingredient

The present invention relates to a novel compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating poly(ADP-ribose)polymerase-1 (PARP-1) related diseases containing the compound as an active ingredient. The novel PARP-1 inhibitory compound according to the present invention exhibits an excellent PARP-1 inhibitory effect at a concentration of nanomol unit and further exhibits an excellent cytoprotective effect (cell death inhibitory effect) on ophthalmic diseases or disorders, especially on retinal diseases. The composition containing the compound as an active ingredient is useful as a composition for preventing or treating PARP-1 related diseases, for example, ophthalmic diseases or disorders.(AA) Example 37(BB) Example 39COPYRIGHT KIPO 2018

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse "tube-in-tube" flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.

COMPOUNDS ACTIVE TOWARDS BROMODOMAINS

Disclosed are compounds towards bromodomains, pharmaceutical compositions containing the compounds and use of the compounds in therapy.

SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.