N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide
CAS No.:1449792-90-8
Molecular Formula:C₂₈H₃₃FN₂O₂
Molecular Weight:448.581
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

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Chemical Property of N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

Chemical Property:

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Technology Process of N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

There total 3 articles about N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1449792-34-0
3-[(4,4-diphenylbutyl)(methyl)amino]dihydrofuran-2(3H)-one

: 140-75-0
para-fluorobenzylamine

: 1449792-90-8
N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

Guidance literature:: In tetrahydrofuran; for 48h; Reflux;
DOI:10.1016/j.bmc.2013.06.038

Reference yield:

: N-methyl-4,4-diphenylbut-3-en-1-amine

: 1449792-90-8
N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon / ethanol / 9 h / 20 °C

2: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 24 h / 20 °C

3: tetrahydrofuran / 48 h / Reflux

With palladium 10% on activated carbon; tetrabutylammomium bromide; potassium carbonate; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.bmc.2013.06.038

Reference yield:

: 52238-39-8
N-methyl-4,4-diphenylbutan-1-amine

: 1449792-90-8
N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 24 h / 20 °C

2: tetrahydrofuran / 48 h / Reflux

With tetrabutylammomium bromide; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmc.2013.06.038