2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

Base Information

Chemical Name:2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide
CAS No.:1562664-78-1
Molecular Formula:C₂₄H₂₂ClN₃OS
Molecular Weight:435.977
Hs Code.:

Synonyms:2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

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Technology Process of 2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

There total 6 articles about 2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1562664-70-3
1-(3,5-dimethylbenzyl)-1,3-dihydro-2H-benzo[d]imidazole-2-thione

: 3289-76-7
N-(2-chlorophenyl)chloroacetamide

: 1562664-78-1
2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.12.045

Reference yield:

: 88-74-4
2-nitro-aniline

: 1562664-78-1
2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: hydrogenchloride; zinc / ethanol / 1 h / Reflux

3: pyridine / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; zinc; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.045

Reference yield:

: 27129-86-8
1-bromomethyl-3,5-dimethylbenzene

: 1562664-78-1
2-{[1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-chlorophenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: hydrogenchloride; zinc / ethanol / 1 h / Reflux

3: pyridine / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; zinc; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.045