3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

Base Information

Chemical Name:3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one
CAS No.:1313389-13-7
Molecular Formula:C₁₆H₁₃N₅O₃S
Molecular Weight:355.377
Hs Code.:

Synonyms:3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

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Chemical Property of 3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

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Technology Process of 3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

There total 5 articles about 3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1313389-03-5
3-benzyl-8-(3-methoxyisoxazol-5-yl)-1H-purine-2,6(3H,7H)-dione

: 1313389-13-7
3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

Guidance literature:: With pyridine; tetraphosphorus decasulfide; at 140 ℃; for 5h;
DOI:10.1021/jm2004738

Reference yield:

: C₁₁H₈N₄O₄

: 1313389-13-7
3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium dithionite

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 24 h

2.3: 1.5 h

3.1: pyridine; tetraphosphorus decasulfide / 5 h / 140 °C

With pyridine; sodium dithionite; tetraphosphorus decasulfide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm2004738

Reference yield:

: 13626-59-0
3-methoxyisoxazole-5-carboxylic acid

: 1313389-13-7
3-benzyl-1,6-dihydro-8-(3-methoxyisoxazol-5-yl)-6-thioxo-3H-purin-2(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 24 h

1.3: 1.5 h

2.1: pyridine; tetraphosphorus decasulfide / 5 h / 140 °C

With pyridine; tetraphosphorus decasulfide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm2004738