(4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Base Information

Chemical Name:(4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol
CAS No.:1299446-10-8
Molecular Formula:C₂₄H₂₄FN₃O₂
Molecular Weight:405.472
Hs Code.:

Synonyms:(4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

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Chemical Property of (4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

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Technology Process of (4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

There total 10 articles about (4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1299446-63-1
2-{(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(pyridin-2-yl)ethanol

: 1299446-10-8
(4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: 2-{(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(pyridin-2-yl)ethanol; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With water; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 754235-92-2
(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-(prop-2-en-1yl)-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 1299446-10-8
(4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1.25 h / 0 - 20 °C

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: n-butyllithium / diethyl ether / 0.33 h / -78 °C

3.2: 0.33 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With 2,6-dimethylpyridine; osmium(VIII) oxide; n-butyllithium; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;

Reference yield:

: 1299446-55-1
(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-(prop-2-en-1yl)-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 1299446-10-8
(4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: n-butyllithium / diethyl ether / 0.33 h / -78 °C

2.2: 0.33 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With osmium(VIII) oxide; n-butyllithium; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; water; acetone;