(3S)-1-phenyl-3--2-butanone

Base Information

• Chemical Name: (3S)-1-phenyl-3--2-butanone
• CAS No.: 116785-66-1
• Molecular Formula: C₂₉H₂₅NO
• Molecular Weight: 403.524
• Mol file: 116785-66-1.mol

Synonyms:(3S)-1-phenyl-3--2-butanone

Chemical Property of (3S)-1-phenyl-3--2-butanone

Chemical Property:

Purity/Quality:

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Technology Process of (3S)-1-phenyl-3--2-butanone

There total 1 articles about (3S)-1-phenyl-3--2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S)-1-phenyl-3--2-butanol → (3S)-1-phenyl-3--2-butanone (116785-66-1)

Guidance literature:

With N-chloro-succinimide; dimethylsulfide; triethylamine; Yield given. Multistep reaction; 1.) toluene, -25 deg C, 5 h, 2.) toluene, 10 min; to r.t., 15 min;

DOI:10.1021/ja00230a027

Reference yield:

(3S)-1-phenyl-3--2-butanone (116785-66-1) → (R)-2-Phenylpropionic acid (7782-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) potassium hexamethyldisilazane / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.5 h

2: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature

3: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H₂O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2

With hydrogenchloride; potassium hexamethyldisilazane; hydrogen; N-benzyl-trimethylammonium hydroxide; periodic acid; palladium on activated charcoal; In methanol; water;

DOI:10.1021/ja00230a027

Reference yield:

(3S)-1-phenyl-3--2-butanone (116785-66-1) → (2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide (17609-56-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) potassium hexamethyldisilazane / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.5 h

2: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature

3: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H₂O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2

4: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -18 deg C, 60 s, 2.) -18 deg C, 30 min

With 4-methyl-morpholine; hydrogenchloride; potassium hexamethyldisilazane; hydrogen; N-benzyl-trimethylammonium hydroxide; periodic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; water;

DOI:10.1021/ja00230a027

Downstream raw materials:

(2S,4R)-2--4-phenyl-3-pentanone

(R)-2-Phenylpropionic acid

(2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide