(2R)-2-Phenyl-N-((1R)-1-phenylethyl)propanamide

Base Information

Chemical Name:(2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide
CAS No.:17609-56-2
Molecular Formula:C₁₇H₁₉NO
Molecular Weight:253.344
Hs Code.:

Synonyms:(2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide

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Technology Process of (2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide

There total 14 articles about (2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 201230-82-2
carbon monoxide

: 60418-67-9
(S)-2-Phenyl-N-((R)-1-phenyl-ethyl)-propionamide

: 17609-56-2
(2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); hydroxylamine hydrochloride; ruphos; at 120 ℃; for 12h; under 15201 Torr; Overall yield = 96 %; Autoclave;

Reference yield:

: 116785-72-9
(4S)-2-phenyl-4--1-penten-3-one

: 17609-56-2
(2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 25 percent / hydrogen / Rh6H₅)3>3Cl / ethanol; methanol / 48 h

2: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature

3: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H₂O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2

4: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -18 deg C, 60 s, 2.) -18 deg C, 30 min

With 4-methyl-morpholine; hydrogenchloride; hydrogen; N-benzyl-trimethylammonium hydroxide; periodic acid; isobutyl chloroformate; palladium on activated charcoal; Wilkinson's catalyst; In methanol; ethanol; water;
DOI:10.1021/ja00230a027

Reference yield:

: (S)-2-Phenyl-4-(9-phenyl-9H-fluoren-9-ylamino)-pent-1-en-3-ol

: 17609-56-2
(2R*)-2-Phenyl-N-((1R*)-1-phenylethyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-chlorosuccinimide, dimethyl sulfide, 2.) triethylamine / 1.) toluene, -25 deg C, 5 h, 2.) toluene, 10 min; to r.t., 15 min

2: 25 percent / hydrogen / Rh6H₅)3>3Cl / ethanol; methanol / 48 h

3: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature

4: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H₂O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2

5: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -18 deg C, 60 s, 2.) -18 deg C, 30 min

With 4-methyl-morpholine; hydrogenchloride; N-chloro-succinimide; dimethylsulfide; hydrogen; N-benzyl-trimethylammonium hydroxide; periodic acid; triethylamine; isobutyl chloroformate; palladium on activated charcoal; Wilkinson's catalyst; In methanol; ethanol; water;
DOI:10.1021/ja00230a027