methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Base Information

Chemical Name:methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate
CAS No.:77405-78-8
Molecular Formula:C₃₃H₃₀N₄O₈
Molecular Weight:610.623
Hs Code.:

Synonyms:methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

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Chemical Property of methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

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Technology Process of methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

There total 23 articles about methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 96898-28-1
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-hydroxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

: 74-88-4
methyl iodide

: 77405-78-8
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 65 ℃; for 21h;
DOI:10.1021/ja00306a024

Reference yield:

: 83220-14-8
dimethyl 4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2,5-dicarboxylate

: 77405-78-8
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1021/jo00152a049

Reference yield:

: 96898-26-9
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-(6-hydroxy-5-nitro-quinolin-2-yl)-3-methyl-pyridine-2,5-dicarboxylic acid

: 77405-78-8
methyl 5-amino-4-<2-(benzyloxy)-3,4-dimethoxyphenyl>-6-(6-methoxy-5-nitro-2-quinolyl)-3-methylpyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: HCl (10percent) / 18 h / 25 °C

2: 1.) (PhO)2P(O)N₃, Et₃N / 1.) C₆H₆, 80 deg C, 2.5 h; 2.) H₂O-C₆H₆, 80 deg C, 1 h

3: 94 percent / K₂CO₃ / tetrahydrofuran / 21 h / 65 °C

With hydrogenchloride; diphenyl phosphoryl azide; potassium carbonate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja00306a024