(4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile

Base Information

• Chemical Name: (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile
• CAS No.: 92778-11-5
• Molecular Formula: C₁₇H₂₁NO₃
• Molecular Weight: 287.359
• Mol file: 92778-11-5.mol

Synonyms:(4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile

Chemical Property of (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile

There total 3 articles about (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethylene glycol (107-21-1) + p-methoxyphenyl-1'cyano-1'dimethyl-2,3 cyclopentanone (89237-29-6,89300-40-3,89300-43-6,89300-44-7,106400-26-4) → (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile (92778-11-5)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

Reference yield:

cyclopent-2-enone (930-30-3) → (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile (92778-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) dimethoxyethane, hexane -50 deg C, 35 min; 2.) 10 min -50 deg C, 2 h 30 min -30 deg C

2: 95 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With toluene-4-sulfonic acid; In benzene;

Reference yield:

lihio p-methoxyphenylacetonitrile (167320-57-2) → (4-Methoxy-phenyl)-((6R,7R)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-acetonitrile (92778-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) dimethoxyethane, hexane -50 deg C, 35 min; 2.) 10 min -50 deg C, 2 h 30 min -30 deg C

2: 95 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With toluene-4-sulfonic acid; In benzene;

upstream raw materials:

ethylene glycol

p-methoxyphenyl-1'cyano-1'dimethyl-2,3 cyclopentanone

cyclopent-2-enone

lihio p-methoxyphenylacetonitrile

Downstream raw materials:

(2S,3R)-3-(4-Methoxy-benzoyl)-2-methyl-cyclopentanone

(4-Methoxy-phenyl)-((6R,7S)-6-methyl-1,4-dioxa-spiro[4.4]non-7-yl)-methanone