Technology Process of 3-formyl-4-methoxy-5-trifluoromethoxybenzoic acid
There total 7 articles about 3-formyl-4-methoxy-5-trifluoromethoxybenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-1-diethoxymethyl-2-methoxy-3-trifluoromethoxybenzene;
With
methylmagnesium bromide; magnesium;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
carbon dioxide;
In
tetrahydrofuran;
at 0 ℃;
for 0.75h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1.25 h / -60 °C / Inert atmosphere
2.2: 0.5 h / 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran; cyclohexane / 15 h / 60 °C
4.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
6.1: Amberlyst-15 / hexane / 3 h / Reflux
7.1: methylmagnesium bromide; magnesium / tetrahydrofuran / 1 h / 0 - 20 °C
7.2: 0.75 h / 0 °C
7.3: 0.5 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; methylmagnesium bromide; water; potassium carbonate; magnesium;
Amberlyst-15;
In
tetrahydrofuran; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
3.1: Amberlyst-15 / hexane / 3 h / Reflux
4.1: methylmagnesium bromide; magnesium / tetrahydrofuran / 1 h / 0 - 20 °C
4.2: 0.75 h / 0 °C
4.3: 0.5 h / 20 °C
With
N-Bromosuccinimide; methylmagnesium bromide; potassium carbonate; magnesium;
Amberlyst-15;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
