[(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester
• CAS No.: 118252-76-9
• Molecular Formula: C₂₄H₂₉BrN₂O₄
• Molecular Weight: 489.409
• Mol file: 118252-76-9.mol

Synonyms:[(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

Chemical Property of [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

There total 2 articles about [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(S)-1-((S)-1-Benzyl-3-diazo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester (150831-74-6) → [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester (118252-76-9)

Guidance literature:

With hydrogen bromide; In acetic acid;

DOI:10.1016/S0960-894X(00)00451-0

Reference yield:

N-benzyloxycarbonyl-L-leucyl-L-phenylalanine (6401-63-4) → [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester (118252-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: IBCF; NMM

2: HBr / acetic acid

With 4-methyl-morpholine; hydrogen bromide; isobutyl chloroformate; In acetic acid; 1: Substitution / 2: Bromination;

DOI:10.1016/S0960-894X(00)00451-0

Reference yield:

diphenyl-phosphinic acid (1707-03-5) + [(S)-1-((S)-1-Benzyl-3-bromo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester (118252-76-9) → Z-Leu-Phe-CH2DPP

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1021/jm00002a002

upstream raw materials:

[(S)-1-((S)-1-Benzyl-3-diazo-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

N-benzyloxycarbonyl-L-leucyl-L-phenylalanine