methyl 3,5-dichloro-α-cyano-benzeneacetic acid

Base Information

• Chemical Name: methyl 3,5-dichloro-α-cyano-benzeneacetic acid
• CAS No.: 1443329-58-5
• Molecular Formula: C₁₀H₇Cl₂NO₂
• Molecular Weight: 244.077
• Mol file: 1443329-58-5.mol

Synonyms:methyl 3,5-dichloro-α-cyano-benzeneacetic acid

Chemical Property of methyl 3,5-dichloro-α-cyano-benzeneacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 3,5-dichloro-α-cyano-benzeneacetic acid

There total 1 articles about methyl 3,5-dichloro-α-cyano-benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3,5-dichlorophenylacetonitrile (52516-37-7) + carbonic acid dimethyl ester (616-38-6) → methyl 3,5-dichloro-α-cyano-benzeneacetic acid (1443329-58-5)

Guidance literature:

With sodium methylate; In methanol; toluene; at 50 ℃; for 3.5h;

Reference yield: 79.0%

methyl 3,5-dichloro-α-cyano-benzeneacetic acid (1443329-58-5) → 1,3-dimethyl 2-(3,5-dichlorophenyl)propanedioate (1443329-48-3)

Guidance literature:

With hydrogenchloride; In methanol; at 45 - 50 ℃; for 1.83333h;

Reference yield:

methyl 3,5-dichloro-α-cyano-benzeneacetic acid (1443329-58-5) → 2-(3,5-dichlorophenyl)propanedioyl dichloride (1443329-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 1.83 h / 45 - 50 °C

2: potassium hydroxide / water / 20 - 35 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 0.5 h / 23 - 25 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; potassium hydroxide; In methanol; water; toluene;

upstream raw materials:

3,5-dichlorophenylacetonitrile

carbonic acid dimethyl ester

Downstream raw materials:

2-(3,5-dichlorophenyl)propanedioyl dichloride

1-[(2-chloro-5-thiazolyl)methyl]-3-(3,5-dichlorophenyl)-2-hydroxy-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

1,3-dimethyl 2-(3,5-dichlorophenyl)propanedioate

Refernces