1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

Base Information

Chemical Name:1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide
CAS No.:1374202-04-6
Molecular Formula:C₁₈H₁₉N₇O₅S
Molecular Weight:445.459
Hs Code.:

Synonyms:1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

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Chemical Property of 1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

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Technology Process of 1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

There total 3 articles about 1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 542-85-8
Ethyl isothiocyanate

: 1374202-30-8
2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetohydrazide

: 1374202-04-6
1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

Guidance literature:: In ethanol; for 4h; Reflux;
DOI:10.1016/j.bmc.2012.03.021

Reference yield:

: 1309666-18-9
7-(4-nitrobenzyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one

: 1374202-04-6
1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

1.2: 2 h / Reflux

2.1: hydrazine hydrate / ethanol / 1 h / Reflux

3.1: ethanol / 4 h / Reflux

With hydrazine hydrate; potassium carbonate; In ethanol; acetone;
DOI:10.1016/j.bmc.2012.03.021

Reference yield:

: 1374202-28-4
ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

: 1374202-04-6
1-(2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1 h / Reflux

2: ethanol / 4 h / Reflux

With hydrazine hydrate; In ethanol;
DOI:10.1016/j.bmc.2012.03.021