ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

Base Information

Chemical Name:ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate
CAS No.:1374202-28-4
Molecular Formula:C₁₇H₁₆N₄O₆
Molecular Weight:372.337
Hs Code.:

Synonyms:ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

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Chemical Property of ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

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Technology Process of ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

There total 1 articles about ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1309666-18-9
7-(4-nitrobenzyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one

: 105-36-2
ethyl bromoacetate

: 1374202-28-4
ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

Guidance literature:: 7-(4-nitrobenzyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one; With potassium carbonate; In acetone; for 4h; Reflux;

ethyl bromoacetate; In acetone; for 2h; Reflux;
DOI:10.1016/j.bmc.2012.03.021

Reference yield: 87.0%

: 1374202-28-4
ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

: 1374202-30-8
2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetohydrazide

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Reflux;
DOI:10.1016/j.bmc.2012.03.021

Reference yield:

: 1374202-28-4
ethyl 2-(7-(4-nitrobenzyl)-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetate

: 1374202-24-0
7-(4-nitrobenzyl)-5-((4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 1 h / Reflux

2: ethanol / 4 h / Reflux

3: sodium hydrogencarbonate / ethanol; water / 1 h / 20 °C

With hydrazine hydrate; sodium hydrogencarbonate; In ethanol; water;
DOI:10.1016/j.bmc.2012.03.021