N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

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Chemical Name:N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide
CAS No.:1186231-64-0
Molecular Formula:C₂₉H₃₀N₄O₆
Molecular Weight:530.58
Hs Code.:

Synonyms:N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

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Chemical Property of N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

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Technology Process of N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

There total 10 articles about N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1186231-63-9
2-[4-({[3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinolin-2-yl]carbonyl}amino)piperidin-1-yl]-2-oxoethyl acetate

: 1186231-64-0
N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.07.039

Reference yield:

: 6315-94-2
ethyl 2,4-dichloroquinoline-3-carboxylate

: 1186231-64-0
N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium acetate / acetic acid / 20?h / 120?°C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 15?min / Cooling with ice

2.2: 1 h / Cooling with ice

3.1: triethylamine / ethanol / 12 h / 85 °C

4.1: sodium ethanolate / ethanol / 18 h / 50 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 4 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; ethanol / 18 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

8.1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

9.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

With sodium ethanolate; sodium acetate; sodium hydride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.039

Reference yield:

: 99429-64-8
ethyl ester of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

: 1186231-64-0
N-[1-(Hydroxyacetyl)piperidin-4-yl]-3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 15?min / Cooling with ice

1.2: 1 h / Cooling with ice

2.1: triethylamine / ethanol / 12 h / 85 °C

3.1: sodium ethanolate / ethanol / 18 h / 50 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 4 h / 20 °C

5.1: sodium hydroxide / tetrahydrofuran; ethanol / 18 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

8.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

With sodium ethanolate; sodium hydride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.039