ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate
CAS No.:1186188-23-7
Molecular Formula:C₂₀H₁₆ClNO₄
Molecular Weight:369.804
Hs Code.:

Synonyms:ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

There total 4 articles about ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 70-11-1
α-bromoacetophenone

: 99429-64-8
ethyl ester of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

: 1186188-23-7
ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

Guidance literature:: ethyl ester of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; Cooling with ice;

α-bromoacetophenone; In N,N-dimethyl-formamide; mineral oil; for 1h; Cooling with ice;
DOI:10.1016/j.bmc.2012.07.039

Reference yield:

: 6315-94-2
ethyl 2,4-dichloroquinoline-3-carboxylate

: 1186188-23-7
ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate / acetic acid / 20?h / 120?°C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 15?min / Cooling with ice

2.2: 1 h / Cooling with ice

With sodium acetate; sodium hydride; In acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.039

Reference yield:

: 105-53-3
diethyl malonate

: 1186188-23-7
ethyl 4-chloro-2-oxo-1-(2-oxo-2-phenylethyl)-1,2-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 14.5 h / 20 - 140 °C

2.1: trichlorophosphate / 6 h / 110 °C

3.1: sodium acetate / acetic acid / 20?h / 120?°C

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 15?min / Cooling with ice

4.2: 1 h / Cooling with ice

With sodium ethanolate; sodium acetate; sodium hydride; trichlorophosphate; In ethanol; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.039